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Article: Postmortem changes in endothelium-dependent and independent responses of porcine coronary arteries

TitlePostmortem changes in endothelium-dependent and independent responses of porcine coronary arteries
Authors
Issue Date1990
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1990, v. 21 n. 1, p. 49-52 How to Cite?
AbstractStudies were performed in porcine left circumflex coronary arteries to determine the time course of changes in their responses to smooth muscle and endothelial cell agonists following death. The pigs were kept at room temperature for 3, 6, 12 and 24 hr after death before removing the arteries, and the responses compared with fresh arteries. Rings of the arteries were mounted in organ chambers filled with modified Krebs-Ringer solution for isometric tension recording. Fresh rings with endothelium relaxed with stretching, whereas 3- and 6-hr rings developed an increase in tension and often rhythmic activity. In 3-hr rings, there were diminished contractile responses to KCl and serotonin. The contractile responses to prostaglandin F(2α) were depressed at 3 and 6 hr. At 6 hr, rings from six of 14 pigs failed to contract and the responses of the other eight to histamine and serotonin but not to KCl or acetylcholine, were depressed compared to fresh rings. 6hr after death endothelium-mediated relaxation to bradykinin and calcium ionophore A-23187 were depressed while endothelium-mediated as well as direct smooth muscle relaxation by adenosine diphosphate did not change. These studies indicate that caution must be observed in interpreting the findings in autopsy specimens examined as early as 3 hr after death.
Persistent Identifierhttp://hdl.handle.net/10722/170972
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVedernikov, YPen_US
dc.contributor.authorAarhus, Len_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:40Z-
dc.date.available2012-10-30T06:11:40Z-
dc.date.issued1990en_US
dc.identifier.citationGeneral Pharmacology, 1990, v. 21 n. 1, p. 49-52en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/170972-
dc.description.abstractStudies were performed in porcine left circumflex coronary arteries to determine the time course of changes in their responses to smooth muscle and endothelial cell agonists following death. The pigs were kept at room temperature for 3, 6, 12 and 24 hr after death before removing the arteries, and the responses compared with fresh arteries. Rings of the arteries were mounted in organ chambers filled with modified Krebs-Ringer solution for isometric tension recording. Fresh rings with endothelium relaxed with stretching, whereas 3- and 6-hr rings developed an increase in tension and often rhythmic activity. In 3-hr rings, there were diminished contractile responses to KCl and serotonin. The contractile responses to prostaglandin F(2α) were depressed at 3 and 6 hr. At 6 hr, rings from six of 14 pigs failed to contract and the responses of the other eight to histamine and serotonin but not to KCl or acetylcholine, were depressed compared to fresh rings. 6hr after death endothelium-mediated relaxation to bradykinin and calcium ionophore A-23187 were depressed while endothelium-mediated as well as direct smooth muscle relaxation by adenosine diphosphate did not change. These studies indicate that caution must be observed in interpreting the findings in autopsy specimens examined as early as 3 hr after death.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAdenosine Diphosphate - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBradykinin - Pharmacologyen_US
dc.subject.meshCalcimycin - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHistamine - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshPostmortem Changesen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.titlePostmortem changes in endothelium-dependent and independent responses of porcine coronary arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(90)90594-Cen_US
dc.identifier.pmid2105259-
dc.identifier.scopuseid_2-s2.0-0025021540en_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.spage49en_US
dc.identifier.epage52en_US
dc.identifier.isiWOS:A1990CJ60600009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVedernikov, YP=35461855900en_US
dc.identifier.scopusauthoridAarhus, L=7003305335en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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