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- Scopus: eid_2-s2.0-0025006867
- PMID: 2172201
- WOS: WOS:A1990DV92200040
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Article: Epithelium, contractile tone, and responses to relaxing agonists in canine bronchi
Title | Epithelium, contractile tone, and responses to relaxing agonists in canine bronchi |
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Authors | |
Keywords | 5- hydroxytryptamine acetylcholine adenosine 3',5'-cyclic monophosphate airways epithelium-derived relaxing factor forskolin guanosine 3',5'-cyclic monophosphate indomethacin isoproterenol LY83583 nitric oxide prostaglandin E2 sodium nitroprusside |
Issue Date | 1990 |
Citation | Journal Of Applied Physiology, 1990, v. 69 n. 2, p. 678-685 How to Cite? |
Abstract | Experiments were conducted in canine bronchi to determine whether the effect of epithelium removal on relaxations was affected by the contractile agent used to induce active force and the degree of contraction. Pairs of fourth-order bronchi with and without epithelium were suspended in organ chambers in physiological salt solution (95% O2-5% CO2, 37°C). The bronchi were contracted to the concentration of acetylcholine or 5-hydroxytryptamine that resulted in a contraction that was 40 or 80% of the response to 10-4 M of the agonist (ED40 or ED80). Epithelium removal reduced relaxations to isoproterenol and sodium nitroprusside during contraction to the ED80 but not the ED40 of acetylcholine. Responses to forskolin were not affected. Bronchi were significantly more sensitive to relaxing agonists in the presence of 5-hydroxytryptamine; there was no effect on epithelium removal or level of contraction. Thus 1) the influence of epithelium on bronchial relaxation is greatest during high degrees of cholinergic tone and 2) experimental conditions influence the effect of epithelium removal on relaxation. |
Persistent Identifier | http://hdl.handle.net/10722/170971 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | StuartSmith, K | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:39Z | - |
dc.date.available | 2012-10-30T06:11:39Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Journal Of Applied Physiology, 1990, v. 69 n. 2, p. 678-685 | en_US |
dc.identifier.issn | 0161-7567 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170971 | - |
dc.description.abstract | Experiments were conducted in canine bronchi to determine whether the effect of epithelium removal on relaxations was affected by the contractile agent used to induce active force and the degree of contraction. Pairs of fourth-order bronchi with and without epithelium were suspended in organ chambers in physiological salt solution (95% O2-5% CO2, 37°C). The bronchi were contracted to the concentration of acetylcholine or 5-hydroxytryptamine that resulted in a contraction that was 40 or 80% of the response to 10-4 M of the agonist (ED40 or ED80). Epithelium removal reduced relaxations to isoproterenol and sodium nitroprusside during contraction to the ED80 but not the ED40 of acetylcholine. Responses to forskolin were not affected. Bronchi were significantly more sensitive to relaxing agonists in the presence of 5-hydroxytryptamine; there was no effect on epithelium removal or level of contraction. Thus 1) the influence of epithelium on bronchial relaxation is greatest during high degrees of cholinergic tone and 2) experimental conditions influence the effect of epithelium removal on relaxation. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Applied Physiology | en_US |
dc.subject | 5- hydroxytryptamine | - |
dc.subject | acetylcholine | - |
dc.subject | adenosine 3',5'-cyclic monophosphate | - |
dc.subject | airways | - |
dc.subject | epithelium-derived relaxing factor | - |
dc.subject | forskolin | - |
dc.subject | guanosine 3',5'-cyclic monophosphate | - |
dc.subject | indomethacin | - |
dc.subject | isoproterenol | - |
dc.subject | LY83583 | - |
dc.subject | nitric oxide | - |
dc.subject | prostaglandin E2 | - |
dc.subject | sodium nitroprusside | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bronchi - Drug Effects - Physiology | en_US |
dc.subject.mesh | Cyclic Amp - Metabolism | en_US |
dc.subject.mesh | Cyclic Gmp - Metabolism | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Epithelium - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Forskolin - Pharmacology | en_US |
dc.subject.mesh | Isoproterenol - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects - Physiology | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects - Physiology | en_US |
dc.subject.mesh | Nitric Oxide - Pharmacology | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.title | Epithelium, contractile tone, and responses to relaxing agonists in canine bronchi | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 2172201 | - |
dc.identifier.scopus | eid_2-s2.0-0025006867 | en_US |
dc.identifier.volume | 69 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 678 | en_US |
dc.identifier.epage | 685 | en_US |
dc.identifier.isi | WOS:A1990DV92200040 | - |
dc.identifier.scopusauthorid | StuartSmith, K=6701396133 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0161-7567 | - |