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Article: Differential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dog

TitleDifferential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dog
Authors
Issue Date1989
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1989, v. 249 n. 1, p. 52-55 How to Cite?
AbstractExperiments were performed to determine the effect of ergonovine on adrenergic neurotransmission in the blood vessel wall. Strips of canine left circumflex coronary arteries and saphenous veins were incubated with [3H]norepinephrine and suspended for superfusion. Ergonovine (10-6 M) decreased the overflow of [3H]norepinephrine to a modest degree in the coronary artery, whereas a profound inhibition of overflow was observed in the saphenous vein. Methiothepin, but not rauwolscine, reversed the inhibitory effect of ergonovine in both blood vessels. Treatment with atropine or droperidol did not alter the response to ergonovine in the coronary artery. The results demonstrate that ergonovine, by activating prejunctional serotonergic receptors, inhibits adrenergic neurotransmission to a greater extent in the saphenous vein than in the coronary artery. The differential effect of ergonovine on norepinephrine release in these vessels may provide evidence for heterogeneity in the prejunctional modulation of adrenergic neurotransmission.
Persistent Identifierhttp://hdl.handle.net/10722/170950
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorO'rourke, STen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:34Z-
dc.date.available2012-10-30T06:11:34Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1989, v. 249 n. 1, p. 52-55en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170950-
dc.description.abstractExperiments were performed to determine the effect of ergonovine on adrenergic neurotransmission in the blood vessel wall. Strips of canine left circumflex coronary arteries and saphenous veins were incubated with [3H]norepinephrine and suspended for superfusion. Ergonovine (10-6 M) decreased the overflow of [3H]norepinephrine to a modest degree in the coronary artery, whereas a profound inhibition of overflow was observed in the saphenous vein. Methiothepin, but not rauwolscine, reversed the inhibitory effect of ergonovine in both blood vessels. Treatment with atropine or droperidol did not alter the response to ergonovine in the coronary artery. The results demonstrate that ergonovine, by activating prejunctional serotonergic receptors, inhibits adrenergic neurotransmission to a greater extent in the saphenous vein than in the coronary artery. The differential effect of ergonovine on norepinephrine release in these vessels may provide evidence for heterogeneity in the prejunctional modulation of adrenergic neurotransmission.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Vessels - Drug Effects - Secretionen_US
dc.subject.meshDogsen_US
dc.subject.meshErgonovine - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Secretionen_US
dc.subject.meshPerfusionen_US
dc.subject.meshReceptors, Serotonin - Drug Effectsen_US
dc.subject.meshSaphenous Vein - Drug Effects - Secretionen_US
dc.titleDifferential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2709336-
dc.identifier.scopuseid_2-s2.0-0024505819en_US
dc.identifier.volume249en_US
dc.identifier.issue1en_US
dc.identifier.spage52en_US
dc.identifier.epage55en_US
dc.identifier.isiWOS:A1989U279300009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridO'Rourke, ST=7005313078en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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