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Article: The role of potassium and sodium-calcium exchange currents in the action potential durations of normal Purkinje fibres and Purkinje fibres surviving infarction

TitleThe role of potassium and sodium-calcium exchange currents in the action potential durations of normal Purkinje fibres and Purkinje fibres surviving infarction
Authors
Issue Date1989
PublisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org
Citation
Cardiovascular Research, 1989, v. 23 n. 5, p. 410-416 How to Cite?
AbstractVentricular arrhythmias following myocardial infarction may originate from subendocardial Purkinje fibres in the infarcted area. The role of potassium and sodium-calcium exchange currents on action potential duration was therefore investigated in Purkinje fibres surviving infarction and in normal Purkinje fibres. Barium was used to reduce potassium conductance and replacement of sodium chloride by lithium chloride was used to reduce the sodium-calcium exchange current. Barium (1 x 10 -5 to 3 x 10 -5 M) produced a concentration dependent lenghthening of action potential duration in normal Purkinje fibres but these concentrations had no effect in Purkinje fibres surviving infarction. The resting membrane potential, activation voltage, amplitude and V̇(max) were decreased in Purkinje fibres surviving infarction and in barium treated fibres v normal Purkinje fibres. These results show that action potential characteristics of barium treated normal Purkinje fibres closely resemble those seen in Purkinje fibres surviving infarction. A similar reduction of action potential duration was seen in normal Purkinje fibres, fibres surviving infarction and barium treated fibres when the sodium 'window' current was decreased by lignocaine. Without any effect on the V̇(max), the replacement of sodium chloride by lithium chloride resulted in a similar effect on the action potential duration in normal Purkinje fibres and fibres surviving infarction. The results show that the longer action potential duration found in Purkinje fibres surviving infarction can be explained by a decrease of the potassium conductance and not by an increase of the sodium 'window' current or the sodium-calcium exchange current.
Persistent Identifierhttp://hdl.handle.net/10722/170922
ISSN
2015 Impact Factor: 5.465
2015 SCImago Journal Rankings: 2.897
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBril, Aen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:26Z-
dc.date.available2012-10-30T06:11:26Z-
dc.date.issued1989en_US
dc.identifier.citationCardiovascular Research, 1989, v. 23 n. 5, p. 410-416en_US
dc.identifier.issn0008-6363en_US
dc.identifier.urihttp://hdl.handle.net/10722/170922-
dc.description.abstractVentricular arrhythmias following myocardial infarction may originate from subendocardial Purkinje fibres in the infarcted area. The role of potassium and sodium-calcium exchange currents on action potential duration was therefore investigated in Purkinje fibres surviving infarction and in normal Purkinje fibres. Barium was used to reduce potassium conductance and replacement of sodium chloride by lithium chloride was used to reduce the sodium-calcium exchange current. Barium (1 x 10 -5 to 3 x 10 -5 M) produced a concentration dependent lenghthening of action potential duration in normal Purkinje fibres but these concentrations had no effect in Purkinje fibres surviving infarction. The resting membrane potential, activation voltage, amplitude and V̇(max) were decreased in Purkinje fibres surviving infarction and in barium treated fibres v normal Purkinje fibres. These results show that action potential characteristics of barium treated normal Purkinje fibres closely resemble those seen in Purkinje fibres surviving infarction. A similar reduction of action potential duration was seen in normal Purkinje fibres, fibres surviving infarction and barium treated fibres when the sodium 'window' current was decreased by lignocaine. Without any effect on the V̇(max), the replacement of sodium chloride by lithium chloride resulted in a similar effect on the action potential duration in normal Purkinje fibres and fibres surviving infarction. The results show that the longer action potential duration found in Purkinje fibres surviving infarction can be explained by a decrease of the potassium conductance and not by an increase of the sodium 'window' current or the sodium-calcium exchange current.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.orgen_US
dc.relation.ispartofCardiovascular Researchen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBarium - Pharmacologyen_US
dc.subject.meshBiological Transporten_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshChlorides - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Conduction System - Metabolismen_US
dc.subject.meshIon Channels - Drug Effects - Metabolismen_US
dc.subject.meshLidocaine - Pharmacologyen_US
dc.subject.meshLithium - Pharmacologyen_US
dc.subject.meshLithium Chlorideen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction - Metabolism - Physiopathologyen_US
dc.subject.meshPotassium - Physiologyen_US
dc.subject.meshPurkinje Fibers - Drug Effects - Metabolism - Physiopathologyen_US
dc.subject.meshSodium - Physiologyen_US
dc.titleThe role of potassium and sodium-calcium exchange currents in the action potential durations of normal Purkinje fibres and Purkinje fibres surviving infarctionen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/cvr/23.5.410-
dc.identifier.pmid2482131-
dc.identifier.scopuseid_2-s2.0-0024369052en_US
dc.identifier.volume23en_US
dc.identifier.issue5en_US
dc.identifier.spage410en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:A1989U510400006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBril, A=7006161753en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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