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Article: Arachidonic acid evokes epithelium-dependent relaxations in canine airways

TitleArachidonic acid evokes epithelium-dependent relaxations in canine airways
Authors
Issue Date1988
Citation
Journal Of Applied Physiology, 1988, v. 65 n. 5, p. 2170-2180 How to Cite?
AbstractResponses to arachidonate were examined in rings with and without epithelium of lobar, segmental, and subsegmental canine bronchi. Arachidonate evoked epithelium-dependent relaxations, which were less pronounced in subsegmental bronchi and abolished by indomethacin and meclofenamate. Nordihydroguaiaretic acid (NDGA) and nafazatrom reduced epithelium-dependent relaxations only in lobar but unsmashed epithelium-independent relaxations to arachidonate in all bronchi. Prostaglandin E2 and prostacyclin relaxed all tissues similarly. In lobar bronchi without epithelium, basal release of prostaglandin E2 was reduced by indomethacin but unaffected by NDGA. Arachidonate augmented prostaglandin E2 release more in subsegmental than in lobar bronchi with epithelium; in bronchi without epithelium the rise was absent (lobar) or attenuated (subsegmental). Arachidonate augmented the release of 6-ketoprostaglandin F(1α) more in lobar bronchi with than without epithelium; this was inhibited by indomethacin, but not NDGA. Thus arachidonate releases prostalglandin E2 (possibly produced by cyclooxygenase inaccessible to inhibitors and activated by lipoxygenase products) but not prostacyclin from the epithelium. Heterogeneity in response to arachidonate is not due to different sensitivity to, or production of, prostaglandins.
Persistent Identifierhttp://hdl.handle.net/10722/170909
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStuartSmith, Ken_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:23Z-
dc.date.available2012-10-30T06:11:23Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Applied Physiology, 1988, v. 65 n. 5, p. 2170-2180en_US
dc.identifier.issn0161-7567en_US
dc.identifier.urihttp://hdl.handle.net/10722/170909-
dc.description.abstractResponses to arachidonate were examined in rings with and without epithelium of lobar, segmental, and subsegmental canine bronchi. Arachidonate evoked epithelium-dependent relaxations, which were less pronounced in subsegmental bronchi and abolished by indomethacin and meclofenamate. Nordihydroguaiaretic acid (NDGA) and nafazatrom reduced epithelium-dependent relaxations only in lobar but unsmashed epithelium-independent relaxations to arachidonate in all bronchi. Prostaglandin E2 and prostacyclin relaxed all tissues similarly. In lobar bronchi without epithelium, basal release of prostaglandin E2 was reduced by indomethacin but unaffected by NDGA. Arachidonate augmented prostaglandin E2 release more in subsegmental than in lobar bronchi with epithelium; in bronchi without epithelium the rise was absent (lobar) or attenuated (subsegmental). Arachidonate augmented the release of 6-ketoprostaglandin F(1α) more in lobar bronchi with than without epithelium; this was inhibited by indomethacin, but not NDGA. Thus arachidonate releases prostalglandin E2 (possibly produced by cyclooxygenase inaccessible to inhibitors and activated by lipoxygenase products) but not prostacyclin from the epithelium. Heterogeneity in response to arachidonate is not due to different sensitivity to, or production of, prostaglandins.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonate Lipoxygenases - Antagonists & Inhibitorsen_US
dc.subject.meshArachidonic Aciden_US
dc.subject.meshArachidonic Acids - Pharmacologyen_US
dc.subject.meshBronchi - Drug Effects - Physiologyen_US
dc.subject.meshCyclooxygenase Inhibitorsen_US
dc.subject.meshDinoprostone - Pharmacology - Secretionen_US
dc.subject.meshDogsen_US
dc.subject.meshEpithelium - Drug Effects - Physiologyen_US
dc.subject.meshEpoprostenol - Pharmacology - Secretionen_US
dc.subject.meshFemaleen_US
dc.subject.meshLeukotrienes - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.titleArachidonic acid evokes epithelium-dependent relaxations in canine airwaysen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3145278-
dc.identifier.scopuseid_2-s2.0-0024241618en_US
dc.identifier.volume65en_US
dc.identifier.issue5en_US
dc.identifier.spage2170en_US
dc.identifier.epage2180en_US
dc.identifier.isiWOS:A1988Q972100037-
dc.identifier.scopusauthoridStuartSmith, K=6701396133en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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