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Article: The effect of cold on adrenergic neurotransmission in canine saphenous arteries and veins

TitleThe effect of cold on adrenergic neurotransmission in canine saphenous arteries and veins
Authors
Issue Date1988
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Proceedings Of The Society For Experimental Biology And Medicine, 1988, v. 187 n. 4, p. 506-512 How to Cite?
AbstractThe effect of severe cold (5 to 10°C) on adrenergic neurotransmission was compared in the isolated cutaneous (saphenous) artery and vein of the dog. The vein contracted to sympathetic nerve stimulation at temperatures as low as 10°C; higher temperatures were needed for the artery to contract. Both blood vessels contracted to exogenous norepinephrine at temperatures as low as 5°C. However, the contractile response to exogenous norepinephrine was less in the saphenous artery, and contractions to high K+ solution were depressed by cooling more in the artery than in the vein. During electrical stimulation of the sympathetic nerves in saphenous arteries and veins previously incubated with labeled norepinephrine, progressive cooling from 37 to 5°C caused a sharp decline in overflow of [3H]norepinephrine and its metabolites. However, overflow of labeled norepinephrine in both blood vessels continued at very cold temperatures. Thus the inability of the saphenous artery to contract to sympathetic nerve stimulation at 10°C can be explained by a greater sensitivity of the arterial smooth muscle to the direct depressant effect of cold, rather than to a differential release or metabolism or norepinephrine in the arterial wall or a loss of responsiveness to norepinephrine at very cold temperatures.
Persistent Identifierhttp://hdl.handle.net/10722/170896
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRusch, NJen_US
dc.contributor.authorAarhus, LLen_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:20Z-
dc.date.available2012-10-30T06:11:20Z-
dc.date.issued1988en_US
dc.identifier.citationProceedings Of The Society For Experimental Biology And Medicine, 1988, v. 187 n. 4, p. 506-512en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/170896-
dc.description.abstractThe effect of severe cold (5 to 10°C) on adrenergic neurotransmission was compared in the isolated cutaneous (saphenous) artery and vein of the dog. The vein contracted to sympathetic nerve stimulation at temperatures as low as 10°C; higher temperatures were needed for the artery to contract. Both blood vessels contracted to exogenous norepinephrine at temperatures as low as 5°C. However, the contractile response to exogenous norepinephrine was less in the saphenous artery, and contractions to high K+ solution were depressed by cooling more in the artery than in the vein. During electrical stimulation of the sympathetic nerves in saphenous arteries and veins previously incubated with labeled norepinephrine, progressive cooling from 37 to 5°C caused a sharp decline in overflow of [3H]norepinephrine and its metabolites. However, overflow of labeled norepinephrine in both blood vessels continued at very cold temperatures. Thus the inability of the saphenous artery to contract to sympathetic nerve stimulation at 10°C can be explained by a greater sensitivity of the arterial smooth muscle to the direct depressant effect of cold, rather than to a differential release or metabolism or norepinephrine in the arterial wall or a loss of responsiveness to norepinephrine at very cold temperatures.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofProceedings of the Society for Experimental Biology and Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Physiologyen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshIsometric Contractionen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNorepinephrine - Metabolism - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Physiologyen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleThe effect of cold on adrenergic neurotransmission in canine saphenous arteries and veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3353400-
dc.identifier.scopuseid_2-s2.0-0023900732en_US
dc.identifier.volume187en_US
dc.identifier.issue4en_US
dc.identifier.spage506en_US
dc.identifier.epage512en_US
dc.identifier.isiWOS:A1988M834200018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRusch, NJ=7005728816en_US
dc.identifier.scopusauthoridAarhus, LL=7003305335en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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