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Article: Potassium-induced endothelium-dependent rhythmic activity in the canine basilar artery

TitlePotassium-induced endothelium-dependent rhythmic activity in the canine basilar artery
Authors
Issue Date1988
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1988, v. 12 n. 1, p. 37-41 How to Cite?
AbstractRings of canine basilar arteries with and without endothelium were suspended for isometric tension recording in modified Krebs-Ringer bicarbonate solution. Increased extracellular concentrations of potassium (3-20 mM) caused rhythmic activity in rings with endothelium. This activity was reduced by the removal of the endothelium and by exposure to indomethacin, meclofenamate, diltiazem, or ouabain; it was not affected by tetrodotoxin, bretylium tosylate, phentolamine, propranolol, atropine, methiothepin, and cimetidine. Prostaglandin F(2α) and E2 caused concentration-dependent increases in the frequency and the amplitude of this rhythmic activity and reversed the inhibitory effect of indomethacin and meclofenamate. Prostacyclin abolished the activity. These results suggest that increasing the concentration of extracellular potassium causes rhythmic activity in canine basilar arteries because of the production and/or release by the endothelium of products of cyclooxygenase such as prostaglandin F(2α) and E2. These may initiate the contraction while prostacyclin triggers the relaxation phase of rhythmic activity, possibly by activating Na+, K+-ATPase of the vascular smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170893
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKatusic, ZSen_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:19Z-
dc.date.available2012-10-30T06:11:19Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1988, v. 12 n. 1, p. 37-41en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170893-
dc.description.abstractRings of canine basilar arteries with and without endothelium were suspended for isometric tension recording in modified Krebs-Ringer bicarbonate solution. Increased extracellular concentrations of potassium (3-20 mM) caused rhythmic activity in rings with endothelium. This activity was reduced by the removal of the endothelium and by exposure to indomethacin, meclofenamate, diltiazem, or ouabain; it was not affected by tetrodotoxin, bretylium tosylate, phentolamine, propranolol, atropine, methiothepin, and cimetidine. Prostaglandin F(2α) and E2 caused concentration-dependent increases in the frequency and the amplitude of this rhythmic activity and reversed the inhibitory effect of indomethacin and meclofenamate. Prostacyclin abolished the activity. These results suggest that increasing the concentration of extracellular potassium causes rhythmic activity in canine basilar arteries because of the production and/or release by the endothelium of products of cyclooxygenase such as prostaglandin F(2α) and E2. These may initiate the contraction while prostacyclin triggers the relaxation phase of rhythmic activity, possibly by activating Na+, K+-ATPase of the vascular smooth muscle.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonic Acids - Metabolism - Pharmacologyen_US
dc.subject.meshBasilar Artery - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshEpoprostenol - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshOuabain - Pharmacologyen_US
dc.subject.meshPeriodicityen_US
dc.subject.meshPotassium - Physiologyen_US
dc.subject.meshProstaglandins - Pharmacologyen_US
dc.subject.meshTetraethylammonium Compounds - Pharmacologyen_US
dc.subject.meshVasomotor System - Physiologyen_US
dc.titlePotassium-induced endothelium-dependent rhythmic activity in the canine basilar arteryen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198807000-00005-
dc.identifier.pmid2459532-
dc.identifier.scopuseid_2-s2.0-0023893539en_US
dc.identifier.volume12en_US
dc.identifier.issue1en_US
dc.identifier.spage37en_US
dc.identifier.epage41en_US
dc.identifier.isiWOS:A1988N953400005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKatusic, ZS=7006971465en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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