File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Potassium-free solution prevents the action but not the release of endothelium-derived relaxing factor

TitlePotassium-free solution prevents the action but not the release of endothelium-derived relaxing factor
Authors
Issue Date1988
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1988, v. 145 n. 3, p. 351-355 How to Cite?
AbstractExposure to a K+-free solution reversibly inhibited the acetylcholine-induced relaxation in perfused canine femoral artery segments with endothelium and in superfused bioassay femoral artery rings without endothelium. Infusion of 6.7 mM K+ into the K+-free perfusate downstream of the perfused artery restored the acetylcholine-induced relaxation in the bioassay ring, whereas no relaxation was observed in the perfused segment still exposed to the K+-free solution. These data demonstrate that the K+-free solution depresses the endothelium-dependent relaxation to acetylcholine in femoral arteries by preventing the action, but not the production, of endothelium-derived relaxing factor.
Persistent Identifierhttp://hdl.handle.net/10722/170887
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRubanyi, GMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:17Z-
dc.date.available2012-10-30T06:11:17Z-
dc.date.issued1988en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1988, v. 145 n. 3, p. 351-355en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170887-
dc.description.abstractExposure to a K+-free solution reversibly inhibited the acetylcholine-induced relaxation in perfused canine femoral artery segments with endothelium and in superfused bioassay femoral artery rings without endothelium. Infusion of 6.7 mM K+ into the K+-free perfusate downstream of the perfused artery restored the acetylcholine-induced relaxation in the bioassay ring, whereas no relaxation was observed in the perfused segment still exposed to the K+-free solution. These data demonstrate that the K+-free solution depresses the endothelium-dependent relaxation to acetylcholine in femoral arteries by preventing the action, but not the production, of endothelium-derived relaxing factor.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Agents - Biosynthesis - Pharmacologyen_US
dc.subject.meshDinoprosten_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemoral Artery - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNitric Oxideen_US
dc.subject.meshPerfusionen_US
dc.subject.meshPotassium - Metabolismen_US
dc.subject.meshProstaglandins F - Pharmacologyen_US
dc.subject.meshVasodilator Agents - Biosynthesis - Pharmacologyen_US
dc.titlePotassium-free solution prevents the action but not the release of endothelium-derived relaxing factoren_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(88)90441-4en_US
dc.identifier.pmid3258243en_US
dc.identifier.scopuseid_2-s2.0-0023840537en_US
dc.identifier.volume145en_US
dc.identifier.issue3en_US
dc.identifier.spage351en_US
dc.identifier.epage355en_US
dc.identifier.isiWOS:A1988L828500016-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridRubanyi, GM=7005517991en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats