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Article: Are there interactions between S2-serotonergic and α1-adrenergic receptors in isolated canine arteries?

TitleAre there interactions between S2-serotonergic and α1-adrenergic receptors in isolated canine arteries?
Authors
Issue Date1988
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1988, v. 11 SUPPL. 1, p. S16-S21 How to Cite?
AbstractExperiments were performed to examine the interaction(s) between α1-adrenergic and S2-serotonergic receptors of vascular smooth muscle of the dog. Rings of isolated coronary and femoral arteries (without endothelium) were suspended for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution. 5-Hydroxytryptamine (serotonin) augmented the responsiveness to norepinephrine in the coronary artery (log shift at ED50 of the concentration-response curve: 2.9-fold). In the femoral artery, the contractions to either norepinephrine or the partial α1-adrenergic agonist St 587 were unchanged by serotonin. Ketanserin (10- M) augmented the response to the full α1-adrenergic agonist phenylephrine, but not to that of St 587; at 5 x 10-9 M, it depressed the contractions to phenylephrine. Ketanserin did not affect the α1-adrenergic blocking properties of prazosin. By contrast, prazosin, in a concentration selective for α1-adrenergic receptors, potentiated the inhibitory effect of ketanserin on contractions evoked by serotonin. These experiments suggest different interactions between S2-serotonergic and α1-adrenergic receptors in the canine coronary and femoral artery.
Persistent Identifierhttp://hdl.handle.net/10722/170866
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuscher, TFen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:10Z-
dc.date.available2012-10-30T06:11:10Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1988, v. 11 SUPPL. 1, p. S16-S21en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170866-
dc.description.abstractExperiments were performed to examine the interaction(s) between α1-adrenergic and S2-serotonergic receptors of vascular smooth muscle of the dog. Rings of isolated coronary and femoral arteries (without endothelium) were suspended for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution. 5-Hydroxytryptamine (serotonin) augmented the responsiveness to norepinephrine in the coronary artery (log shift at ED50 of the concentration-response curve: 2.9-fold). In the femoral artery, the contractions to either norepinephrine or the partial α1-adrenergic agonist St 587 were unchanged by serotonin. Ketanserin (10- M) augmented the response to the full α1-adrenergic agonist phenylephrine, but not to that of St 587; at 5 x 10-9 M, it depressed the contractions to phenylephrine. Ketanserin did not affect the α1-adrenergic blocking properties of prazosin. By contrast, prazosin, in a concentration selective for α1-adrenergic receptors, potentiated the inhibitory effect of ketanserin on contractions evoked by serotonin. These experiments suggest different interactions between S2-serotonergic and α1-adrenergic receptors in the canine coronary and femoral artery.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Vessels - Drug Effects - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemoral Artery - Drug Effects - Physiologyen_US
dc.subject.meshKetanserin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshReceptors, Serotonin - Physiologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.titleAre there interactions between S2-serotonergic and α1-adrenergic receptors in isolated canine arteries?en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2459508-
dc.identifier.scopuseid_2-s2.0-0023677253en_US
dc.identifier.volume11en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spageS16en_US
dc.identifier.epageS21en_US
dc.identifier.isiWOS:A1988P544300005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuscher, TF=18935805600en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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