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Article: Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension

TitleAntihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension
Authors
Issue Date1987
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 1987, v. 9 n. 6 II SUPPL., p. III-193-III-197 How to Cite?
AbstractEndothelium-dependent responses are impaired in various models of hypertension. The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant rats (DR) on a high or low sodium diet. The rats were given either a diet containing 8% NaCl or 0.1% NaCl for 8 weeks or a diet containing 8% NaCl and a combination of reserpine, hydrochlorothiazide, and hydralazine for 8 or 2 weeks. DS on the 8% NaCl diet developed hypertension, while the other rats did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed hypertension in DS and lowered blood pressure in DR on the 8% NaCl diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, acetylcholine, adenosine 5'-diphosphate, and thrombin caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% NaCl compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, sodium nitroprusside. These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of cardiovascular complications in patients with hypertension.
Persistent Identifierhttp://hdl.handle.net/10722/170854
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702

 

DC FieldValueLanguage
dc.contributor.authorLuscher, TFen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorRaij, Len_US
dc.date.accessioned2012-10-30T06:11:07Z-
dc.date.available2012-10-30T06:11:07Z-
dc.date.issued1987en_US
dc.identifier.citationHypertension, 1987, v. 9 n. 6 II SUPPL., p. III-193-III-197en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170854-
dc.description.abstractEndothelium-dependent responses are impaired in various models of hypertension. The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant rats (DR) on a high or low sodium diet. The rats were given either a diet containing 8% NaCl or 0.1% NaCl for 8 weeks or a diet containing 8% NaCl and a combination of reserpine, hydrochlorothiazide, and hydralazine for 8 or 2 weeks. DS on the 8% NaCl diet developed hypertension, while the other rats did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed hypertension in DS and lowered blood pressure in DR on the 8% NaCl diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, acetylcholine, adenosine 5'-diphosphate, and thrombin caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% NaCl compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, sodium nitroprusside. These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of cardiovascular complications in patients with hypertension.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntihypertensive Agents - Pharmacologyen_US
dc.subject.meshAorta - Physiopathologyen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDiet, Sodium-Restricteden_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshEndothelium - Physiopathologyen_US
dc.subject.meshHypertension - Chemically Induced - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshSodium Chlorideen_US
dc.subject.meshVasoconstrictionen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleAntihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertensionen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3596786-
dc.identifier.scopuseid_2-s2.0-0023268884en_US
dc.identifier.volume9en_US
dc.identifier.issue6 II SUPPL.en_US
dc.identifier.spageIIIen_US
dc.identifier.epage193en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuscher, TF=18935805600en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridRaij, L=7006228846en_US

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