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Article: Endothelium-dependent contraction to stretch in canine basilar arteries

TitleEndothelium-dependent contraction to stretch in canine basilar arteries
Authors
Issue Date1987
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1987, v. 252 n. 3, p. 21/3 How to Cite?
AbstractStretch applied to isolated canine basilar arteries caused the development of active tension in rings with endothelium but not in those in which the endothelium had been removed. Blockade of calcium entry with diltiazem or inhibition of cyclooxygenase with indomethacin abolished the endothelium-dependent response to stretch. These observations suggest that the endothelium may contribute to the autoregulation of cerebral blood flow during increases in transmural pressure by the increased production and/or release of prostaglandins, which causes activation of the underlying vascular smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170846
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKatusic, ZSen_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:05Z-
dc.date.available2012-10-30T06:11:05Z-
dc.date.issued1987en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1987, v. 252 n. 3, p. 21/3en_US
dc.identifier.issn0363-6135en_US
dc.identifier.urihttp://hdl.handle.net/10722/170846-
dc.description.abstractStretch applied to isolated canine basilar arteries caused the development of active tension in rings with endothelium but not in those in which the endothelium had been removed. Blockade of calcium entry with diltiazem or inhibition of cyclooxygenase with indomethacin abolished the endothelium-dependent response to stretch. These observations suggest that the endothelium may contribute to the autoregulation of cerebral blood flow during increases in transmural pressure by the increased production and/or release of prostaglandins, which causes activation of the underlying vascular smooth muscle.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasilar Artery - Physiologyen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCyclooxygenase Inhibitorsen_US
dc.subject.meshDiethylcarbamazine - Pharmacologyen_US
dc.subject.meshDiltiazem - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEndothelium - Physiologyen_US
dc.subject.meshHomeostasisen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshPapaverine - Pharmacologyen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshUridine Triphosphate - Pharmacologyen_US
dc.subject.meshVasoconstrictionen_US
dc.titleEndothelium-dependent contraction to stretch in canine basilar arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3103472-
dc.identifier.scopuseid_2-s2.0-0023182673en_US
dc.identifier.volume252en_US
dc.identifier.issue3en_US
dc.identifier.spage21/3en_US
dc.identifier.isiWOS:A1987G536500030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKatusic, ZS=7006971465en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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