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Article: Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17β-estradiol

TitleAlpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17β-estradiol
Authors
Issue Date1987
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1987, v. 240 n. 2, p. 466-470 How to Cite?
AbstractExperiments were designed to determine the effect of estrogen pretreatment on alpha adrenergic responsiveness of blood vessels of the rabbit. Rabbits were ovariectomized and, after 8 days of recovery, treated with 17β-estradiol (100 μg i.m.; estrogen group) or solvent (control group) for 4 days. Rings of saphenous vein and femoral artery (both without endothelium) were mounted for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution (37°C), gassed with 95% O2-5% CO2. All experiments were performed in the presence of inhibitors of neuronal uptake, extraneuronal uptake and beta adrenoceptors. In the saphenous vein, the estrogen treatment did not significantly affect the concentration-effect curves evoked by norepinephrine (either under control conditions or after alpha-1 or alpha-2 adrenergic blockade), phenylephrine (an alpha-1 adrenergic agonist) or UK 14,304 (an alpha-2 adrenergic agonist). In the femoral artery, estrogen treatment depressed the contractile responses evoked by norepinephrine (under control conditions) but not those produced by phenylephrine; UK 14,304 did not evoke a contractile response. The depressant effect of estrogen treatment on the concentration-effect curve to norepinephrine in the femoral artery was prevented by the alpha-2 adrenergic antagonist, rauwolscine. The results in the femoral artery but not in the saphenous vein suggest that estrogens depress alpha-2 but not alpha-1 adrenergic responsiveness. In the femoral artery, alpha-2 adrenoceptor stimulation does not cause contraction per se but apparently can facilitate alpha-1 adrenergic responses. This probably results from a reduced density of alpha-2 adrenoceptors in this blood vessel. Thus, the inhibitory influence of estrogen on alpha adrenergic responses of vascular smooth muscle may depend on the density of adrenoceptors (or spare receptors).
Persistent Identifierhttp://hdl.handle.net/10722/170841
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGisclard, Ven_US
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:04Z-
dc.date.available2012-10-30T06:11:04Z-
dc.date.issued1987en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1987, v. 240 n. 2, p. 466-470en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170841-
dc.description.abstractExperiments were designed to determine the effect of estrogen pretreatment on alpha adrenergic responsiveness of blood vessels of the rabbit. Rabbits were ovariectomized and, after 8 days of recovery, treated with 17β-estradiol (100 μg i.m.; estrogen group) or solvent (control group) for 4 days. Rings of saphenous vein and femoral artery (both without endothelium) were mounted for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution (37°C), gassed with 95% O2-5% CO2. All experiments were performed in the presence of inhibitors of neuronal uptake, extraneuronal uptake and beta adrenoceptors. In the saphenous vein, the estrogen treatment did not significantly affect the concentration-effect curves evoked by norepinephrine (either under control conditions or after alpha-1 or alpha-2 adrenergic blockade), phenylephrine (an alpha-1 adrenergic agonist) or UK 14,304 (an alpha-2 adrenergic agonist). In the femoral artery, estrogen treatment depressed the contractile responses evoked by norepinephrine (under control conditions) but not those produced by phenylephrine; UK 14,304 did not evoke a contractile response. The depressant effect of estrogen treatment on the concentration-effect curve to norepinephrine in the femoral artery was prevented by the alpha-2 adrenergic antagonist, rauwolscine. The results in the femoral artery but not in the saphenous vein suggest that estrogens depress alpha-2 but not alpha-1 adrenergic responsiveness. In the femoral artery, alpha-2 adrenoceptor stimulation does not cause contraction per se but apparently can facilitate alpha-1 adrenergic responses. This probably results from a reduced density of alpha-2 adrenoceptors in this blood vessel. Thus, the inhibitory influence of estrogen on alpha adrenergic responses of vascular smooth muscle may depend on the density of adrenoceptors (or spare receptors).en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Vessels - Physiologyen_US
dc.subject.meshEstradiol - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effectsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasomotor System - Drug Effectsen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titleAlpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17β-estradiolen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3027313-
dc.identifier.scopuseid_2-s2.0-0023137661en_US
dc.identifier.volume240en_US
dc.identifier.issue2en_US
dc.identifier.spage466en_US
dc.identifier.epage470en_US
dc.identifier.isiWOS:A1987G081700019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGisclard, V=6505914966en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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