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Article: Serotonin and the vascular wall

TitleSerotonin and the vascular wall
Authors
Issue Date1987
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 1987, v. 14 n. 2, p. 189-203 How to Cite?
AbstractSerotonin possesses both vasoconstrictor and vasodilator properties. The constrictor action of the monoamine can be due to: (a) direct activation of vascular smooth muscle; in most blood vessels, this is mediated by S2-serotonergic receptors; (b) augmentation (amplification) of the action of other endogenous vasoconstrictors such as catecholamines, angiotensin II and the prostanoids; and (c) release of norepinephrine from adrenergic nerves. The dilator action of serotonin can be due to: (a) activation of endothelial cells which release endothelium-derived relaxing factor(s); this response appears to be mediated by S1-serotonergic receptors; (b) direct inhibition of vascular smooth muscle; (c) inhibition of adrenergic neurotransmission by an action on S1-serotonergic prejunctional receptors; and (d) release of other endogenous mediators. The net effect of serotonin on the blood vessel wall depends on: (a) the integrity of the endothelium; (b) the degree of activation of the vascular smooth muscle; (c) the level of sympathetic tone; and (d) local (e.g. P(O2), temperature) and chronic (e.g. blood pressure) modulating factors. S2-serotonergic antagonists prevent the constrictor action of serotonin, and often unmask its dilator potential.
Persistent Identifierhttp://hdl.handle.net/10722/170837
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:03Z-
dc.date.available2012-10-30T06:11:03Z-
dc.date.issued1987en_US
dc.identifier.citationInternational Journal Of Cardiology, 1987, v. 14 n. 2, p. 189-203en_US
dc.identifier.issn0167-5273en_US
dc.identifier.urihttp://hdl.handle.net/10722/170837-
dc.description.abstractSerotonin possesses both vasoconstrictor and vasodilator properties. The constrictor action of the monoamine can be due to: (a) direct activation of vascular smooth muscle; in most blood vessels, this is mediated by S2-serotonergic receptors; (b) augmentation (amplification) of the action of other endogenous vasoconstrictors such as catecholamines, angiotensin II and the prostanoids; and (c) release of norepinephrine from adrenergic nerves. The dilator action of serotonin can be due to: (a) activation of endothelial cells which release endothelium-derived relaxing factor(s); this response appears to be mediated by S1-serotonergic receptors; (b) direct inhibition of vascular smooth muscle; (c) inhibition of adrenergic neurotransmission by an action on S1-serotonergic prejunctional receptors; and (d) release of other endogenous mediators. The net effect of serotonin on the blood vessel wall depends on: (a) the integrity of the endothelium; (b) the degree of activation of the vascular smooth muscle; (c) the level of sympathetic tone; and (d) local (e.g. P(O2), temperature) and chronic (e.g. blood pressure) modulating factors. S2-serotonergic antagonists prevent the constrictor action of serotonin, and often unmask its dilator potential.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.subject.meshCardiotonic Agents - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshReceptors, Serotonin - Physiologyen_US
dc.subject.meshSerotonin - Physiologyen_US
dc.subject.meshVascular Diseases - Physiopathologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleSerotonin and the vascular wallen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0167-5273(87)90008-8-
dc.identifier.pmid3818135-
dc.identifier.scopuseid_2-s2.0-0023088875en_US
dc.identifier.volume14en_US
dc.identifier.issue2en_US
dc.identifier.spage189en_US
dc.identifier.epage203en_US
dc.identifier.isiWOS:A1987F853000008-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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