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Article: Oxytocin causes endothelium-depending relaxations of canine basilar arteries by activating V1-vasopressinergic receptors

TitleOxytocin causes endothelium-depending relaxations of canine basilar arteries by activating V1-vasopressinergic receptors
Authors
Issue Date1986
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1986, v. 236 n. 1, p. 166-170 How to Cite?
AbstractExperiments were designed to study the effects of oxytocin on canine basilar and femoral arteries and to compare these with the effects of vasopressin. Rings of the arteries were suspended in physiological salt solution for isometric tension recording. Oxytocin and vasopressin caused endothelium-dependent relaxation of basilar arteries contracted with prostaglandin F(2α). Vasopressin was more potent than oxytocin. In the femoral artery, in the two hormones caused endothelium-independent contractions with the same order of potency. The relaxation of the basilar artery occurred at lower concentrations of each substance than the contractions of the femoral artery. The relaxations in response to both agonists were inhibited competitively, and the contractions noncompetitively, by the V1-vasopressinergic antagonist d(CH2)5 Tyr(Me)AVP; the antagonist did not affect endothelium-dependent relaxations in response to bradykinin. Thus, both oxytocin and vasopressin cause endothelium-dependent relaxation of the basilar artery by activating V1-vasopressinergic receptors; the contractions of femoral arteries that they cause also may be mediated in part by V1-vasopresinergic receptors.
Persistent Identifierhttp://hdl.handle.net/10722/170823
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKatusic, ZSen_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:01Z-
dc.date.available2012-10-30T06:11:01Z-
dc.date.issued1986en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1986, v. 236 n. 1, p. 166-170en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170823-
dc.description.abstractExperiments were designed to study the effects of oxytocin on canine basilar and femoral arteries and to compare these with the effects of vasopressin. Rings of the arteries were suspended in physiological salt solution for isometric tension recording. Oxytocin and vasopressin caused endothelium-dependent relaxation of basilar arteries contracted with prostaglandin F(2α). Vasopressin was more potent than oxytocin. In the femoral artery, in the two hormones caused endothelium-independent contractions with the same order of potency. The relaxation of the basilar artery occurred at lower concentrations of each substance than the contractions of the femoral artery. The relaxations in response to both agonists were inhibited competitively, and the contractions noncompetitively, by the V1-vasopressinergic antagonist d(CH2)5 Tyr(Me)AVP; the antagonist did not affect endothelium-dependent relaxations in response to bradykinin. Thus, both oxytocin and vasopressin cause endothelium-dependent relaxation of the basilar artery by activating V1-vasopressinergic receptors; the contractions of femoral arteries that they cause also may be mediated in part by V1-vasopresinergic receptors.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine Vasopressin - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshBasilar Artery - Drug Effectsen_US
dc.subject.meshBradykinin - Pharmacologyen_US
dc.subject.meshDeamino Arginine Vasopressin - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium - Drug Effectsen_US
dc.subject.meshFemoral Artery - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOxytocin - Pharmacologyen_US
dc.subject.meshReceptors, Angiotensin - Drug Effectsen_US
dc.subject.meshReceptors, Cell Surface - Drug Effectsen_US
dc.subject.meshReceptors, Vasopressinen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.subject.meshVasopressins - Pharmacologyen_US
dc.titleOxytocin causes endothelium-depending relaxations of canine basilar arteries by activating V1-vasopressinergic receptorsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3001282-
dc.identifier.scopuseid_2-s2.0-0022645675en_US
dc.identifier.volume236en_US
dc.identifier.issue1en_US
dc.identifier.spage166en_US
dc.identifier.epage170en_US
dc.identifier.isiWOS:A1986AXX2600027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKatusic, ZS=7006971465en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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