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Article: Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat

TitleEndothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat
Authors
Issue Date1986
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 1986, v. 8 n. 4, p. 344-348 How to Cite?
AbstractTo study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic aorta with and without endothelium were taken from age-matched male SHR and normotensive Wistar-Kyoto rats (WKY) and suspended for isometric tension recording. Acetylcholine caused endothelium-dependent contractions in quiescent rings from SHR but not in those from WKY. These contractions were inhibited by atropine but not by hexamethonium and were prevented by inhibitors of phospholipase A2 or cyclooxygenase but not by inhibitors of prostacyclin synthetase, thromboxane synthetase, or leukotriene synthetase. Prostaglandin D2, E1, E2, and F(2α) caused concentration-dependent contractions in rings without endothelium from both SHR and WKY; the responses to the highest concentration (10-5 M) of the individual prostaglandins were comparable in both strains. Endothelium-dependent relaxations evoked by high but not by low concentrations of acetylcholine were significantly depressed in SHR as compared with those in WKY (p < 0.05). Indomethacin normalized endothelium-dependent relaxations in SHR. Thus, acetylcholine can activate muscarinic receptors that evoke endothelium-dependent contractions in the aorta of SHR but not in that of WKY. The contration probably is mediated by a cyclooxygenase product(s) other than prostacyclin or thromboxane A2. The reduced endothelium-dependent relaxations to acetylcholine in the SHR probably are not due to a decreased release of endothelium-derived relaxing factor(s) but to the simultaneous release of endothelium-derived contracting substance(s).
Persistent Identifierhttp://hdl.handle.net/10722/170817
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuscher, TFen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:59Z-
dc.date.available2012-10-30T06:10:59Z-
dc.date.issued1986en_US
dc.identifier.citationHypertension, 1986, v. 8 n. 4, p. 344-348en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170817-
dc.description.abstractTo study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic aorta with and without endothelium were taken from age-matched male SHR and normotensive Wistar-Kyoto rats (WKY) and suspended for isometric tension recording. Acetylcholine caused endothelium-dependent contractions in quiescent rings from SHR but not in those from WKY. These contractions were inhibited by atropine but not by hexamethonium and were prevented by inhibitors of phospholipase A2 or cyclooxygenase but not by inhibitors of prostacyclin synthetase, thromboxane synthetase, or leukotriene synthetase. Prostaglandin D2, E1, E2, and F(2α) caused concentration-dependent contractions in rings without endothelium from both SHR and WKY; the responses to the highest concentration (10-5 M) of the individual prostaglandins were comparable in both strains. Endothelium-dependent relaxations evoked by high but not by low concentrations of acetylcholine were significantly depressed in SHR as compared with those in WKY (p < 0.05). Indomethacin normalized endothelium-dependent relaxations in SHR. Thus, acetylcholine can activate muscarinic receptors that evoke endothelium-dependent contractions in the aorta of SHR but not in that of WKY. The contration probably is mediated by a cyclooxygenase product(s) other than prostacyclin or thromboxane A2. The reduced endothelium-dependent relaxations to acetylcholine in the SHR probably are not due to a decreased release of endothelium-derived relaxing factor(s) but to the simultaneous release of endothelium-derived contracting substance(s).en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshAcetylcholine - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracicen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshCytochrome P-450 Enzyme Systemen_US
dc.subject.meshEndothelium - Drug Effectsen_US
dc.subject.meshEpoprostenol - Antagonists & Inhibitors - Biosynthesisen_US
dc.subject.meshHexamethoniumen_US
dc.subject.meshHexamethonium Compounds - Pharmacologyen_US
dc.subject.meshIntramolecular Oxidoreductasesen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Pharmacologyen_US
dc.subject.meshProstaglandins - Pharmacologyen_US
dc.subject.meshQuinacrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSpecies Specificityen_US
dc.titleEndothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive raten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.HYP.8.4.344-
dc.identifier.pmid2870025-
dc.identifier.scopuseid_2-s2.0-0022545417en_US
dc.identifier.volume8en_US
dc.identifier.issue4en_US
dc.identifier.spage344en_US
dc.identifier.epage348en_US
dc.identifier.isiWOS:A1986A811500013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuscher, TF=18935805600en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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