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Article: Effects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats

TitleEffects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats
Authors
Issue Date1986
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHA
Citation
Pharmacology, 1986, v. 32 n. 6, p. 326-334 How to Cite?
AbstractThe effects of verapamil on gastric wall mucus and ulceration were studied in rats which were restrained and exposed to 4°C (stress). Stress for 2 h significantly depleted stomach wall mucus and produced marked gastric glandular ulcers. Verapamil pretreatment (2, 4, 8 or 16 mg/kg), injected intraperitoneally 30 min before experimentation, significantly prevented stress-induced mucus depletion and gastric ulceration; however, it did not itself influence stomach wall mucus levels in nonstressed animals. Intragastric administration of carbenoxolone (100 or 200 mg/kg), also given 30 min before stress, exhibited similar actions as verapamil. A 15% solution of N-acetylcysteine (10 ml/kg), given orally, strongly decreased the mucus content in both nonstress and stress conditions; it induced ulcers in nonstressed rats, and worsened stress ulceration. These effects were not reversed by verapamil pretreatment. The influence of multiple-dose pretreatment with verapamil or carbenoxolone on mucus content and ulceration in the gastric glandular mucosa during stress is also discussed. It is concluded that gastric wall mucus depletion is likely to play an important role in stress ulcer formation; the antiulcer action of verapamil could partly be due to the preservation of mucus.
Persistent Identifierhttp://hdl.handle.net/10722/170809
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 0.645
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorOgle, CWen_US
dc.contributor.authorCho, CHen_US
dc.date.accessioned2012-10-30T06:10:57Z-
dc.date.available2012-10-30T06:10:57Z-
dc.date.issued1986en_US
dc.identifier.citationPharmacology, 1986, v. 32 n. 6, p. 326-334en_US
dc.identifier.issn0031-7012en_US
dc.identifier.urihttp://hdl.handle.net/10722/170809-
dc.description.abstractThe effects of verapamil on gastric wall mucus and ulceration were studied in rats which were restrained and exposed to 4°C (stress). Stress for 2 h significantly depleted stomach wall mucus and produced marked gastric glandular ulcers. Verapamil pretreatment (2, 4, 8 or 16 mg/kg), injected intraperitoneally 30 min before experimentation, significantly prevented stress-induced mucus depletion and gastric ulceration; however, it did not itself influence stomach wall mucus levels in nonstressed animals. Intragastric administration of carbenoxolone (100 or 200 mg/kg), also given 30 min before stress, exhibited similar actions as verapamil. A 15% solution of N-acetylcysteine (10 ml/kg), given orally, strongly decreased the mucus content in both nonstress and stress conditions; it induced ulcers in nonstressed rats, and worsened stress ulceration. These effects were not reversed by verapamil pretreatment. The influence of multiple-dose pretreatment with verapamil or carbenoxolone on mucus content and ulceration in the gastric glandular mucosa during stress is also discussed. It is concluded that gastric wall mucus depletion is likely to play an important role in stress ulcer formation; the antiulcer action of verapamil could partly be due to the preservation of mucus.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHAen_US
dc.relation.ispartofPharmacologyen_US
dc.subject.meshAcetylcysteine - Administration & Dosage - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarbenoxolone - Administration & Dosage - Pharmacologyen_US
dc.subject.meshCold Temperature - Adverse Effectsen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Mucosa - Drug Effectsen_US
dc.subject.meshGlycyrrhetinic Acid - Analogs & Derivativesen_US
dc.subject.meshMucus - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshRestraint, Physicalen_US
dc.subject.meshStomach Ulcer - Physiopathology - Prevention & Controlen_US
dc.subject.meshStress, Physiological - Physiopathologyen_US
dc.subject.meshVerapamil - Administration & Dosage - Pharmacologyen_US
dc.titleEffects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed ratsen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000138188-
dc.identifier.pmid3725888-
dc.identifier.scopuseid_2-s2.0-0022469828en_US
dc.identifier.volume32en_US
dc.identifier.issue6en_US
dc.identifier.spage326en_US
dc.identifier.epage334en_US
dc.identifier.isiWOS:A1986C674900005-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US

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