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Article: The effect of lidocaine on lysophosphatidylcholine-induced cardiac arrhythmias and cellular disturbances

TitleThe effect of lidocaine on lysophosphatidylcholine-induced cardiac arrhythmias and cellular disturbances
Authors
Issue Date1985
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
Citation
Canadian Journal Of Physiology And Pharmacology, 1985, v. 63 n. 7, p. 804-808 How to Cite?
AbstractThe production of arrhythmias in the isolated heart by perfusion with lysophosphatidylcholine has been well documented. However, the role of the lysophospholipid as a physiological factor in the generation of cardiac arrhythmias is not clear. In this study, a pharmacological approach was used to delineate the physiological significance of lysophosphatidylcholine during this cardiac dysfunction. Lidocaine (5-20 mg/L) was found to be effective in the protection of the isolated rat heart from the lysophospholipid-induced arrhythmias at pharmacological concentrations. The effect of lidocaine in the protection of lysophospholipid-induced membrane dysfunction was studied with red blood cells. Lidocaine (2 mg/L) protected red blood cells from hemolysis in the presence of lysophosphatidylcholine. Lidocaine did not inhibit the binding of the lysophospholipid to the red cell membrane, but inhibited hemolysis in a manner similar to cholesterol. The results are consistent with the postulate that lysophosphatidylcholine is a physiological factor in the pathogenesis of cardiac arrhythmias during myocardial ischemia.
Persistent Identifierhttp://hdl.handle.net/10722/170802
ISSN
2015 Impact Factor: 1.704
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNeufeld, KJen_US
dc.contributor.authorLederman, CLen_US
dc.contributor.authorChoy, PCen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:10:55Z-
dc.date.available2012-10-30T06:10:55Z-
dc.date.issued1985en_US
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 1985, v. 63 n. 7, p. 804-808en_US
dc.identifier.issn0008-4212en_US
dc.identifier.urihttp://hdl.handle.net/10722/170802-
dc.description.abstractThe production of arrhythmias in the isolated heart by perfusion with lysophosphatidylcholine has been well documented. However, the role of the lysophospholipid as a physiological factor in the generation of cardiac arrhythmias is not clear. In this study, a pharmacological approach was used to delineate the physiological significance of lysophosphatidylcholine during this cardiac dysfunction. Lidocaine (5-20 mg/L) was found to be effective in the protection of the isolated rat heart from the lysophospholipid-induced arrhythmias at pharmacological concentrations. The effect of lidocaine in the protection of lysophospholipid-induced membrane dysfunction was studied with red blood cells. Lidocaine (2 mg/L) protected red blood cells from hemolysis in the presence of lysophosphatidylcholine. Lidocaine did not inhibit the binding of the lysophospholipid to the red cell membrane, but inhibited hemolysis in a manner similar to cholesterol. The results are consistent with the postulate that lysophosphatidylcholine is a physiological factor in the pathogenesis of cardiac arrhythmias during myocardial ischemia.en_US
dc.languageengen_US
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjppen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.subject.meshAlbumins - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Chemically Induced - Physiopathology - Prevention & Controlen_US
dc.subject.meshCell Membrane - Drug Effectsen_US
dc.subject.meshCholesterol - Pharmacologyen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshErythrocyte Membrane - Metabolismen_US
dc.subject.meshHemolysis - Drug Effectsen_US
dc.subject.meshLidocaine - Pharmacologyen_US
dc.subject.meshLysophosphatidylcholines - Antagonists & Inhibitors - Toxicityen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshVentricular Fibrillation - Blooden_US
dc.titleThe effect of lidocaine on lysophosphatidylcholine-induced cardiac arrhythmias and cellular disturbancesen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1139/y85-133-
dc.identifier.pmid4042015-
dc.identifier.scopuseid_2-s2.0-0022404647en_US
dc.identifier.volume63en_US
dc.identifier.issue7en_US
dc.identifier.spage804en_US
dc.identifier.epage808en_US
dc.identifier.isiWOS:A1985ANY9400006-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridNeufeld, KJ=7003453938en_US
dc.identifier.scopusauthoridLederman, CL=6701809777en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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