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Article: Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa

TitleEffects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa
Authors
Issue Date1985
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 1985, v. 32 n. 4, p. 288-295 How to Cite?
AbstractThe effect of zinc sulphate on stomach ulceration produced by ethanol and indomethacin was examined in rats. Oral or intraperitoneal pretreatment with zinc sulphate (20 mg/kg, expressed as zinc ion) strongly prevented ethanol-, but not indomethacin-induced gastric glandular ulceration. Indomethacin given beforehand did not influence the protective action of zinc sulphate against ethanol-evoked lesions. Ethanol decreased histamine levels, whereas indomethacin reduced the prostaglandin E2 (PGE2) content in the gastric glandular mucosa. The alcohol also elevated the histamine content in gastric secretion. Zinc sulphate reversed the ethanol-induced changes in histamine levels in both mucosa and secretion, but did not modify PGE2 reduction by indomethacin. Zinc sulphate also antagonised protein leakage from the stomach following ethanol administration. It is concluded that gastric ulceration by the currently employed doses of ethanol and indomethacin is caused by different mechanisms. Zinc sulphate prevents histamine-mediated lesions produced by the alcohol, but not ulceration due to PGE2 depletion by indomethacin.
Persistent Identifierhttp://hdl.handle.net/10722/170796
ISSN
2015 Impact Factor: 1.884
2015 SCImago Journal Rankings: 0.953
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCho, CHen_US
dc.contributor.authorOgle, CWen_US
dc.contributor.authorWong, SHen_US
dc.contributor.authorKoo, MWLen_US
dc.date.accessioned2012-10-30T06:10:53Z-
dc.date.available2012-10-30T06:10:53Z-
dc.date.issued1985en_US
dc.identifier.citationDigestion, 1985, v. 32 n. 4, p. 288-295en_US
dc.identifier.issn0012-2823en_US
dc.identifier.urihttp://hdl.handle.net/10722/170796-
dc.description.abstractThe effect of zinc sulphate on stomach ulceration produced by ethanol and indomethacin was examined in rats. Oral or intraperitoneal pretreatment with zinc sulphate (20 mg/kg, expressed as zinc ion) strongly prevented ethanol-, but not indomethacin-induced gastric glandular ulceration. Indomethacin given beforehand did not influence the protective action of zinc sulphate against ethanol-evoked lesions. Ethanol decreased histamine levels, whereas indomethacin reduced the prostaglandin E2 (PGE2) content in the gastric glandular mucosa. The alcohol also elevated the histamine content in gastric secretion. Zinc sulphate reversed the ethanol-induced changes in histamine levels in both mucosa and secretion, but did not modify PGE2 reduction by indomethacin. Zinc sulphate also antagonised protein leakage from the stomach following ethanol administration. It is concluded that gastric ulceration by the currently employed doses of ethanol and indomethacin is caused by different mechanisms. Zinc sulphate prevents histamine-mediated lesions produced by the alcohol, but not ulceration due to PGE2 depletion by indomethacin.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_US
dc.relation.ispartofDigestionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDinoprostoneen_US
dc.subject.meshEthanol - Pharmacologyen_US
dc.subject.meshGastric Mucosa - Drug Effects - Metabolismen_US
dc.subject.meshHistamine - Metabolismen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshProstaglandins E - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshStomach Ulcer - Chemically Induced - Metabolism - Prevention & Controlen_US
dc.subject.meshSulfates - Pharmacology - Therapeutic Useen_US
dc.subject.meshZinc - Pharmacology - Therapeutic Useen_US
dc.subject.meshZinc Sulfateen_US
dc.titleEffects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosaen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000199250-
dc.identifier.pmid3864706-
dc.identifier.scopuseid_2-s2.0-0022380121en_US
dc.identifier.volume32en_US
dc.identifier.issue4en_US
dc.identifier.spage288en_US
dc.identifier.epage295en_US
dc.identifier.isiWOS:A1985AUC3600009-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US
dc.identifier.scopusauthoridWong, SH=13310187400en_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US

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