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Article: Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels.

TitlePrejunctional adrenergic inhibition by aggregating platelets in canine blood vessels.
Authors
Issue Date1985
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1985, v. 249 n. 3 Pt 2, p. H685-689 How to Cite?
AbstractExperiments were performed to determine the effect of aggregating platelets on adrenergic neurotransmission. Rings of canine saphenous veins and left circumflex coronary arteries were incubated with [3H]norepinephrine and suspended for superfusion. Aggregating platelets and exogenous 5-hydroxytryptamine decreased the overflow of [3H]norepinephrine evoked by electrical stimulation of the adrenergic nerve endings. The reduction of transmitter overflow caused by 5-hydroxytryptamine was prevented by the serotonergic antagonist methiothepin in a concentration that did not significantly affect the release of 5-hydroxytryptamine or thromboxane B2 from the aggregating platelets. Methiothepin decreased but did not abolish the inhibitory effect of aggregating platelets on neurotransmitter overflow. These experiments demonstrate that 5-hydroxytryptamine and other substances released from aggregating platelets can exert prejunctional inhibition of adrenergic neurotransmission in isolated blood vessels.
Persistent Identifierhttp://hdl.handle.net/10722/170786
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLorenz, RRen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:51Z-
dc.date.available2012-10-30T06:10:51Z-
dc.date.issued1985en_US
dc.identifier.citationThe American Journal Of Physiology, 1985, v. 249 n. 3 Pt 2, p. H685-689en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170786-
dc.description.abstractExperiments were performed to determine the effect of aggregating platelets on adrenergic neurotransmission. Rings of canine saphenous veins and left circumflex coronary arteries were incubated with [3H]norepinephrine and suspended for superfusion. Aggregating platelets and exogenous 5-hydroxytryptamine decreased the overflow of [3H]norepinephrine evoked by electrical stimulation of the adrenergic nerve endings. The reduction of transmitter overflow caused by 5-hydroxytryptamine was prevented by the serotonergic antagonist methiothepin in a concentration that did not significantly affect the release of 5-hydroxytryptamine or thromboxane B2 from the aggregating platelets. Methiothepin decreased but did not abolish the inhibitory effect of aggregating platelets on neurotransmitter overflow. These experiments demonstrate that 5-hydroxytryptamine and other substances released from aggregating platelets can exert prejunctional inhibition of adrenergic neurotransmission in isolated blood vessels.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Platelets - Metabolismen_US
dc.subject.meshCoronary Vessels - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMethiothepin - Pharmacologyen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNorepinephrine - Physiologyen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshPlatelet Aggregation - Drug Effectsen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshSerotonin - Blood - Pharmacologyen_US
dc.subject.meshThromboxane B2 - Blooden_US
dc.titlePrejunctional adrenergic inhibition by aggregating platelets in canine blood vessels.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid4037113-
dc.identifier.scopuseid_2-s2.0-0022119870en_US
dc.identifier.volume249en_US
dc.identifier.issue3 Pt 2en_US
dc.identifier.spageH685en_US
dc.identifier.epage689en_US
dc.identifier.isiWOS:A1985AQW2900031-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLorenz, RR=7402095192en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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