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Article: Electrophysiological actions of flecainide in normal and infarcted canine purkinje fibers

TitleElectrophysiological actions of flecainide in normal and infarcted canine purkinje fibers
Authors
Issue Date1985
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1985, v. 112 n. 1, p. 57-64 How to Cite?
AbstractThe electrophsiological effects of flecainide, 0.1, 0.5 and 1.0 mg/l, on action potential characteristics were examined in normal Purkinje fibers and Purkinje fibers surviving infarction, at stimulation cycle lengths of 1000 and 300 ms. Overshoot, amplitude and dV/dt(max) were reduced significantly in a dose-dependent manner by flecainide in both normal Purkinje fibers and Purkinje fibers surviving infarction. Action potential duration was shortened by flecainide to a greater extent: at the cycle length of 1000 ms compared to 300 ms; at 50% repolarization compared to 90%; and in normal preparations compared to infarcted preparations. Activation time was increased by flecainide in a dose-dependent manner in both types of preparations. This effect was enhanced at the shorter cycle length. In both normal and infarcted preparations, flecainide shortened the ERP of those having a longer initial ERP and lengthened those with a shorter ERP. This effect was significant only at the stimulation cycle length of 1000 ms. This study indicates that flecainide has properties unique and different from traditional antiarrhythmic drugs.
Persistent Identifierhttp://hdl.handle.net/10722/170768
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKinnaird, AAAen_US
dc.contributor.authorLederman, CLen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:10:46Z-
dc.date.available2012-10-30T06:10:46Z-
dc.date.issued1985en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1985, v. 112 n. 1, p. 57-64en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170768-
dc.description.abstractThe electrophsiological effects of flecainide, 0.1, 0.5 and 1.0 mg/l, on action potential characteristics were examined in normal Purkinje fibers and Purkinje fibers surviving infarction, at stimulation cycle lengths of 1000 and 300 ms. Overshoot, amplitude and dV/dt(max) were reduced significantly in a dose-dependent manner by flecainide in both normal Purkinje fibers and Purkinje fibers surviving infarction. Action potential duration was shortened by flecainide to a greater extent: at the cycle length of 1000 ms compared to 300 ms; at 50% repolarization compared to 90%; and in normal preparations compared to infarcted preparations. Activation time was increased by flecainide in a dose-dependent manner in both types of preparations. This effect was enhanced at the shorter cycle length. In both normal and infarcted preparations, flecainide shortened the ERP of those having a longer initial ERP and lengthened those with a shorter ERP. This effect was significant only at the stimulation cycle length of 1000 ms. This study indicates that flecainide has properties unique and different from traditional antiarrhythmic drugs.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlecainideen_US
dc.subject.meshHeart Conduction System - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroelectrodesen_US
dc.subject.meshMyocardial Infarction - Physiopathologyen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshPurkinje Fibers - Drug Effectsen_US
dc.titleElectrophysiological actions of flecainide in normal and infarcted canine purkinje fibersen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(85)90238-9en_US
dc.identifier.pmid4018138-
dc.identifier.scopuseid_2-s2.0-0021838162en_US
dc.identifier.volume112en_US
dc.identifier.issue1en_US
dc.identifier.spage57en_US
dc.identifier.epage64en_US
dc.identifier.isiWOS:A1985ALG4500007-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridKinnaird, AAA=6603472891en_US
dc.identifier.scopusauthoridLederman, CL=6701809777en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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