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Article: 5-Hydroxytryptamine: Source of activator calcium in human basilar arteries

Title5-Hydroxytryptamine: Source of activator calcium in human basilar arteries
Authors
Issue Date1985
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org
Citation
Stroke, 1985, v. 16 n. 4, p. 718-720 How to Cite?
AbstractWe performed experiments in human cerebral arteries to determine the source of activator calcium during contractions induced by 5-hydroxytryptamine. Rings of human basilar artery obtained at autopsy were mounted for isometric tension recording in organ baths filled with a physiological salt solution. Contractile responses to 5-hydroxytryptamine were virtually abolished in Ca ++-free solution, and inhibited significantly by nimodipine. In both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when KCl was used to contract the vessels. These experiments demonstrate that 5-hydroxytryptamine mediates contraction of the smooth muscle in human basilar artery by increasing membrane permeability to extracellular calcium.
Persistent Identifierhttp://hdl.handle.net/10722/170760
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRusch, NJen_US
dc.contributor.authorChyatte, Den_US
dc.contributor.authorSundt Jr, TMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:44Z-
dc.date.available2012-10-30T06:10:44Z-
dc.date.issued1985en_US
dc.identifier.citationStroke, 1985, v. 16 n. 4, p. 718-720en_US
dc.identifier.issn0039-2499en_US
dc.identifier.urihttp://hdl.handle.net/10722/170760-
dc.description.abstractWe performed experiments in human cerebral arteries to determine the source of activator calcium during contractions induced by 5-hydroxytryptamine. Rings of human basilar artery obtained at autopsy were mounted for isometric tension recording in organ baths filled with a physiological salt solution. Contractile responses to 5-hydroxytryptamine were virtually abolished in Ca ++-free solution, and inhibited significantly by nimodipine. In both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when KCl was used to contract the vessels. These experiments demonstrate that 5-hydroxytryptamine mediates contraction of the smooth muscle in human basilar artery by increasing membrane permeability to extracellular calcium.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.orgen_US
dc.relation.ispartofStrokeen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBasilar Artery - Drug Effectsen_US
dc.subject.meshCalcium - Pharmacologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshCapillary Permeability - Drug Effectsen_US
dc.subject.meshCerebral Arteries - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNicotinic Acids - Pharmacologyen_US
dc.subject.meshNimodipineen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.title5-Hydroxytryptamine: Source of activator calcium in human basilar arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.STR.16.4.718-
dc.identifier.pmid4024184-
dc.identifier.scopuseid_2-s2.0-0021796057en_US
dc.identifier.volume16en_US
dc.identifier.issue4en_US
dc.identifier.spage718en_US
dc.identifier.epage720en_US
dc.identifier.isiWOS:A1985ANH1700027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRusch, NJ=7005728816en_US
dc.identifier.scopusauthoridChyatte, D=7003587726en_US
dc.identifier.scopusauthoridSundt Jr, TM=34572694400en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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