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Article: Contractions of the canine coronary artery in calcium-free solution.

TitleContractions of the canine coronary artery in calcium-free solution.
Authors
Issue Date1984
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1984, v. 247 n. 2 Pt 2, p. H259-263 How to Cite?
AbstractProstaglandin F2 alpha, but not norepinephrine, augments the maximal contractile response to potassium. To examine the mechanism underlying this augmentation, rings of canine coronary artery were studied isometrically in physiological salt solutions of various composition. The contractions evoked by prostaglandin F2 alpha were larger in high-potassium, calcium-free solution than in calcium-free solution. Similar results were obtained using canine saphenous vein and femoral artery. Isoproterenol, but not nimodipine, relaxed the contractions produced by prostaglandin F2 alpha in high-potassium, calcium-free solution. Unlike prostaglandin F2 alpha, norepinephrine failed to constrict rings in high-potassium, calcium-free solution. In calcium-free solution, prostaglandin F2 alpha-induced contractions increased with increasing potassium concentrations, but no enhancement occurred when lithium was substituted for potassium. Rings of coronary artery incubated with calcium-45 did not show changes in prostaglandin F2 alpha-induced calcium-45 efflux following changes in potassium concentration. These results suggest that potassium enhances coronary vascular smooth muscle contraction to prostaglandin F2 alpha, but not norepinephrine, independently of calcium entry.
Persistent Identifierhttp://hdl.handle.net/10722/170745
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRooke, TWen_US
dc.contributor.authorRimele, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:40Z-
dc.date.available2012-10-30T06:10:40Z-
dc.date.issued1984en_US
dc.identifier.citationThe American Journal Of Physiology, 1984, v. 247 n. 2 Pt 2, p. H259-263en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170745-
dc.description.abstractProstaglandin F2 alpha, but not norepinephrine, augments the maximal contractile response to potassium. To examine the mechanism underlying this augmentation, rings of canine coronary artery were studied isometrically in physiological salt solutions of various composition. The contractions evoked by prostaglandin F2 alpha were larger in high-potassium, calcium-free solution than in calcium-free solution. Similar results were obtained using canine saphenous vein and femoral artery. Isoproterenol, but not nimodipine, relaxed the contractions produced by prostaglandin F2 alpha in high-potassium, calcium-free solution. Unlike prostaglandin F2 alpha, norepinephrine failed to constrict rings in high-potassium, calcium-free solution. In calcium-free solution, prostaglandin F2 alpha-induced contractions increased with increasing potassium concentrations, but no enhancement occurred when lithium was substituted for potassium. Rings of coronary artery incubated with calcium-45 did not show changes in prostaglandin F2 alpha-induced calcium-45 efflux following changes in potassium concentration. These results suggest that potassium enhances coronary vascular smooth muscle contraction to prostaglandin F2 alpha, but not norepinephrine, independently of calcium entry.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDinoprosten_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemoral Artery - Drug Effectsen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNicotinic Acids - Pharmacologyen_US
dc.subject.meshNimodipineen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshProstaglandins F - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Drug Effectsen_US
dc.titleContractions of the canine coronary artery in calcium-free solution.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6589964en_US
dc.identifier.scopuseid_2-s2.0-0021140570en_US
dc.identifier.volume247en_US
dc.identifier.issue2 Pt 2en_US
dc.identifier.spageH259en_US
dc.identifier.epage263en_US
dc.identifier.isiWOS:A1984TE85900012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRooke, TW=8757981200en_US
dc.identifier.scopusauthoridRimele, TJ=7004614618en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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