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Article: The interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibers

TitleThe interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibers
Authors
Issue Date1984
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1984, v. 99 n. 1, p. 63-71 How to Cite?
AbstractIntracellular action potentials were recorded from normal canine Purkinje fibers using the standard microelectrode technique. The effects of lidocaine (2 and 5 mg/l), tocainide (10 and 20 mg/l) and verapamil (0.5 and 1.0 mg/l) on action potential characteristics as well as conduction times were measured at cycle lengths of 1000, 800, 600, 500, 400 and 300 ms. Lidocaine and tocainide shortened APD(50%) and APD(90%), and verapamil shortened APD(50%) and lengthened APD(90%). All of these effects were greatest at the longest cycle lengths. A similar interaction of changes in ERP with cycle length was observed for lidocaine and tocainide. Verapamil increased ERP but this effect was not significant. Tocainide and verapamil reduced dV/dt(max) while lidocaine had no significant effect. All three drugs dv/dt(max) and conduction times were observed. These results indicate that many of the electrophysiological effects of lidocaine, tocainide and verapamil are modified by cycle length. We propose that future studies on the electrophysiology of antiarrhythmic drugs should include stimulation both at long and short cycle lengths.
Persistent Identifierhttp://hdl.handle.net/10722/170744
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKinnaird, AAAen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:10:40Z-
dc.date.available2012-10-30T06:10:40Z-
dc.date.issued1984en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1984, v. 99 n. 1, p. 63-71en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170744-
dc.description.abstractIntracellular action potentials were recorded from normal canine Purkinje fibers using the standard microelectrode technique. The effects of lidocaine (2 and 5 mg/l), tocainide (10 and 20 mg/l) and verapamil (0.5 and 1.0 mg/l) on action potential characteristics as well as conduction times were measured at cycle lengths of 1000, 800, 600, 500, 400 and 300 ms. Lidocaine and tocainide shortened APD(50%) and APD(90%), and verapamil shortened APD(50%) and lengthened APD(90%). All of these effects were greatest at the longest cycle lengths. A similar interaction of changes in ERP with cycle length was observed for lidocaine and tocainide. Verapamil increased ERP but this effect was not significant. Tocainide and verapamil reduced dV/dt(max) while lidocaine had no significant effect. All three drugs dv/dt(max) and conduction times were observed. These results indicate that many of the electrophysiological effects of lidocaine, tocainide and verapamil are modified by cycle length. We propose that future studies on the electrophysiology of antiarrhythmic drugs should include stimulation both at long and short cycle lengths.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Arrhythmia Agents - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Conduction System - Drug Effectsen_US
dc.subject.meshLidocaine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPurkinje Fibers - Drug Effects - Physiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTocainideen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleThe interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibersen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(84)90432-1en_US
dc.identifier.pmid6426981-
dc.identifier.scopuseid_2-s2.0-0021355607en_US
dc.identifier.volume99en_US
dc.identifier.issue1en_US
dc.identifier.spage63en_US
dc.identifier.epage71en_US
dc.identifier.isiWOS:A1984SL25400008-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridKinnaird, AAA=6603472891en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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