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Article: Ketanserin and vascular contractions in response to cooling

TitleKetanserin and vascular contractions in response to cooling
Authors
Issue Date1984
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1984, v. 99 n. 4, p. 329-332 How to Cite?
AbstractRings of tibial arteries of the rabbit were suspended for isometric tension recording in organ chambers filled with oxygenated physiological salt solution. 5-Hydroxytryptamine caused contractions which were enhanced by cooling from 37 to 29 ° C. Both the contractions induced by 5-hydroxytryptamine and their augmentation by cooling were inhibited by similar concentrations of the serotonergic 5-HT2 antagonist ketanserin. These experiments demonstrate that cooling augments the responsiveness of peripheral arteries to 5-hydroxytryptamine and that the augmentation is mediated by 5-HT2 serotonergic receptors.
Persistent Identifierhttp://hdl.handle.net/10722/170737
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorDe Ridder, Wen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:38Z-
dc.date.available2012-10-30T06:10:38Z-
dc.date.issued1984en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1984, v. 99 n. 4, p. 329-332en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170737-
dc.description.abstractRings of tibial arteries of the rabbit were suspended for isometric tension recording in organ chambers filled with oxygenated physiological salt solution. 5-Hydroxytryptamine caused contractions which were enhanced by cooling from 37 to 29 ° C. Both the contractions induced by 5-hydroxytryptamine and their augmentation by cooling were inhibited by similar concentrations of the serotonergic 5-HT2 antagonist ketanserin. These experiments demonstrate that cooling augments the responsiveness of peripheral arteries to 5-hydroxytryptamine and that the augmentation is mediated by 5-HT2 serotonergic receptors.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Drug Effectsen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshKetanserinen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSerotonin - Physiologyen_US
dc.subject.meshSerotonin Antagonists - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleKetanserin and vascular contractions in response to coolingen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(84)90140-7-
dc.identifier.pmid6734731-
dc.identifier.scopuseid_2-s2.0-0021248645en_US
dc.identifier.volume99en_US
dc.identifier.issue4en_US
dc.identifier.spage329en_US
dc.identifier.epage332en_US
dc.identifier.isiWOS:A1984SP06200010-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridDe Ridder, W=6602324543en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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