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Article: Adjustments in the peripheral circulation in chronic heart failure

TitleAdjustments in the peripheral circulation in chronic heart failure
Authors
Issue Date1983
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
European Heart Journal, 1983, v. 4 Suppl. A, p. 67-83 How to Cite?
AbstractIn congestive heart failure the increases in sympathetic outflow and circulating catecholamines cause pronounced vasoconstriction in the renal and splanchnic vascular beds, which in the early stages of the disease permits the patient to engage in limited exercise even though the cardiac output does not increase normally. Eventually the muscle and skin flows also decrease reflexly. The widespread peripheral vasoconstriction augments the afterload of the heart. The cutaneous veins are constricted; together with the augmented circulating blood volume due to abnormal renal retention, this contributes to the increase in central venous pressure. The resulting increase in preload initially improves the filling of the heart and shifts the myocardium along its Starling curve. The peripheral venoconstriction helps explain the increased tolerance to orthostatic stress seen in patients with heart failure. Since these reflex vascular adjustments tend to augment both the pre- and the afterload of the heart, pharmacological agents causing dilatation of the systemic veins and/or of the arterioles improve the performance of the failing myocardium.
Persistent Identifierhttp://hdl.handle.net/10722/170704
ISSN
2015 Impact Factor: 15.064
2015 SCImago Journal Rankings: 6.997
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:31Z-
dc.date.available2012-10-30T06:10:31Z-
dc.date.issued1983en_US
dc.identifier.citationEuropean Heart Journal, 1983, v. 4 Suppl. A, p. 67-83en_US
dc.identifier.issn0195-668Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170704-
dc.description.abstractIn congestive heart failure the increases in sympathetic outflow and circulating catecholamines cause pronounced vasoconstriction in the renal and splanchnic vascular beds, which in the early stages of the disease permits the patient to engage in limited exercise even though the cardiac output does not increase normally. Eventually the muscle and skin flows also decrease reflexly. The widespread peripheral vasoconstriction augments the afterload of the heart. The cutaneous veins are constricted; together with the augmented circulating blood volume due to abnormal renal retention, this contributes to the increase in central venous pressure. The resulting increase in preload initially improves the filling of the heart and shifts the myocardium along its Starling curve. The peripheral venoconstriction helps explain the increased tolerance to orthostatic stress seen in patients with heart failure. Since these reflex vascular adjustments tend to augment both the pre- and the afterload of the heart, pharmacological agents causing dilatation of the systemic veins and/or of the arterioles improve the performance of the failing myocardium.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/en_US
dc.relation.ispartofEuropean Heart Journalen_US
dc.subject.meshAdaptation, Physiologicalen_US
dc.subject.meshBlood Circulationen_US
dc.subject.meshCoronary Circulationen_US
dc.subject.meshHeart Failure - Physiopathologyen_US
dc.subject.meshHemodynamicsen_US
dc.subject.meshHumansen_US
dc.subject.meshMechanoreceptors - Physiopathologyen_US
dc.subject.meshModels, Cardiovascularen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshMuscles - Blood Supplyen_US
dc.subject.meshReflex - Physiologyen_US
dc.subject.meshRenal Circulationen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshSplanchnic Circulationen_US
dc.subject.meshVasoconstrictionen_US
dc.subject.meshVasomotor System - Physiopathologyen_US
dc.titleAdjustments in the peripheral circulation in chronic heart failureen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/eurheartj/4.suppl_A.67-
dc.identifier.pmid6840124-
dc.identifier.scopuseid_2-s2.0-0020682788en_US
dc.identifier.volume4en_US
dc.identifier.issueSuppl. Aen_US
dc.identifier.spage67en_US
dc.identifier.epage83en_US
dc.identifier.isiWOS:A1983QG81000012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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