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Article: Antihypertensive properties of ketanserin (R 41 468)

TitleAntihypertensive properties of ketanserin (R 41 468)
Authors
Issue Date1983
Citation
Federation Proceedings, 1983, v. 42 n. 2, p. 182-185 How to Cite?
AbstractThe serotonergic receptor antagonist 3-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl}-2,4-[1H,3H] quinazolinedione (ketanserin) causes dose-dependent inhibition of the effects of 5-hydroxytryptamine (5-HT) on 5-HT2-serotonergic receptors. These receptors mediate facilitation of platelet aggregation, direct vasoconstriction in several arteries and veins, and direct amplification of vasoconstrictor responses to other neurohumoral mediators. Ketanserin does not inhibit vasodilator effects of 5-HT. At higher concentrations, ketanserin has α1-adrenergic blocking properties. The compound causes dose-related reductions in arterial blood pressure in hypertensive animals and humans that are larger and occur at lower doses than in normotensive controls. In humans, the antihypertensive properties of ketanserin do not appear to involve α1-adrenergic inhibition, because the compounds given i.v. (10 mg) do not affect the pressor dose-response curve to phenylephrine.
Persistent Identifierhttp://hdl.handle.net/10722/170695
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorSymoens, Jen_US
dc.contributor.authorJanssen, PAJen_US
dc.date.accessioned2012-10-30T06:10:29Z-
dc.date.available2012-10-30T06:10:29Z-
dc.date.issued1983en_US
dc.identifier.citationFederation Proceedings, 1983, v. 42 n. 2, p. 182-185en_US
dc.identifier.issn0014-9446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170695-
dc.description.abstractThe serotonergic receptor antagonist 3-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl}-2,4-[1H,3H] quinazolinedione (ketanserin) causes dose-dependent inhibition of the effects of 5-hydroxytryptamine (5-HT) on 5-HT2-serotonergic receptors. These receptors mediate facilitation of platelet aggregation, direct vasoconstriction in several arteries and veins, and direct amplification of vasoconstrictor responses to other neurohumoral mediators. Ketanserin does not inhibit vasodilator effects of 5-HT. At higher concentrations, ketanserin has α1-adrenergic blocking properties. The compound causes dose-related reductions in arterial blood pressure in hypertensive animals and humans that are larger and occur at lower doses than in normotensive controls. In humans, the antihypertensive properties of ketanserin do not appear to involve α1-adrenergic inhibition, because the compounds given i.v. (10 mg) do not affect the pressor dose-response curve to phenylephrine.en_US
dc.languageengen_US
dc.relation.ispartofFederation Proceedingsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntihypertensive Agents - Pharmacologyen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHumansen_US
dc.subject.meshKetanserinen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshPlatelet Aggregation - Drug Effectsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effectsen_US
dc.subject.meshSerotonin Antagonists - Pharmacologyen_US
dc.titleAntihypertensive properties of ketanserin (R 41 468)en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6295821-
dc.identifier.scopuseid_2-s2.0-0020598959en_US
dc.identifier.volume42en_US
dc.identifier.issue2en_US
dc.identifier.spage182en_US
dc.identifier.epage185en_US
dc.identifier.isiWOS:A1983QB76100008-
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridSymoens, J=7004568510en_US
dc.identifier.scopusauthoridJanssen, PAJ=36042383000en_US

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