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Article: Effects of lysophosphoglycerides on cardiac arrhythmias

TitleEffects of lysophosphoglycerides on cardiac arrhythmias
Authors
Issue Date1983
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1983, v. 32 n. 12, p. 1325-1330 How to Cite?
AbstractThe accumulation of lysophosphoglycerides has been implicated as an important biochemical factor for cardiac arrhythmia. Recently, we demonstrated that lysophosphatidylcholine caused cardiac arrhythmia in the isolated hamster heart. In this study, the arrhythmogenic nature of various lysophosphoglycerides with respect to acyl chain lengths and base groups were assessed. We demonstrated that all naturally occurring lysolipids tested were arrhythmogenic at 0.05-0.10 mM. Arrhythmia were also observed with Triton X-100 or sodium laurylsulfate at 0.05 - 0.10 mM. These data suggest that no correlation exists between the arrhythmogenic nature of the lysolipids and their critical micelle concentrations. We postulate that arrhythmias are produced by the detergent effect of lysophosphoglycerides.
Persistent Identifierhttp://hdl.handle.net/10722/170694
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_US
dc.contributor.authorWong, Ten_US
dc.contributor.authorChoy, PCen_US
dc.date.accessioned2012-10-30T06:10:28Z-
dc.date.available2012-10-30T06:10:28Z-
dc.date.issued1983en_US
dc.identifier.citationLife Sciences, 1983, v. 32 n. 12, p. 1325-1330en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/170694-
dc.description.abstractThe accumulation of lysophosphoglycerides has been implicated as an important biochemical factor for cardiac arrhythmia. Recently, we demonstrated that lysophosphatidylcholine caused cardiac arrhythmia in the isolated hamster heart. In this study, the arrhythmogenic nature of various lysophosphoglycerides with respect to acyl chain lengths and base groups were assessed. We demonstrated that all naturally occurring lysolipids tested were arrhythmogenic at 0.05-0.10 mM. Arrhythmia were also observed with Triton X-100 or sodium laurylsulfate at 0.05 - 0.10 mM. These data suggest that no correlation exists between the arrhythmogenic nature of the lysolipids and their critical micelle concentrations. We postulate that arrhythmias are produced by the detergent effect of lysophosphoglycerides.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Chemically Induceden_US
dc.subject.meshCricetinaeen_US
dc.subject.meshGlycerophosphates - Pharmacologyen_US
dc.subject.meshLysophosphatidylcholines - Pharmacologyen_US
dc.subject.meshLysophospholipidsen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshOctoxynolen_US
dc.subject.meshPhosphatidylethanolamines - Pharmacologyen_US
dc.subject.meshPhosphatidylglycerols - Pharmacologyen_US
dc.subject.meshPhosphatidylserines - Pharmacologyen_US
dc.subject.meshPolyethylene Glycols - Pharmacologyen_US
dc.subject.meshSodium Dodecyl Sulfate - Pharmacologyen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.titleEffects of lysophosphoglycerides on cardiac arrhythmiasen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0024-3205(83)90806-8-
dc.identifier.pmid6834990-
dc.identifier.scopuseid_2-s2.0-0020582212en_US
dc.identifier.volume32en_US
dc.identifier.issue12en_US
dc.identifier.spage1325en_US
dc.identifier.epage1330en_US
dc.identifier.isiWOS:A1983QD13300005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridWong, T=7403531180en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US

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