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Article: Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets

TitleInhibitory role of the endothelium in the response of isolated coronary arteries to platelets
Authors
Issue Date1983
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1983, v. 221 n. 4607, p. 273-274 How to Cite?
AbstractAggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2α, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets.
Persistent Identifierhttp://hdl.handle.net/10722/170692
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCohen, RAen_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:28Z-
dc.date.available2012-10-30T06:10:28Z-
dc.date.issued1983en_US
dc.identifier.citationScience, 1983, v. 221 n. 4607, p. 273-274en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/170692-
dc.description.abstractAggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2α, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Platelets - Physiologyen_US
dc.subject.meshCoronary Vessels - Physiologyen_US
dc.subject.meshDinoprosten_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshPlatelet Aggregationen_US
dc.subject.meshProstaglandins F - Physiologyen_US
dc.subject.meshSerotonin - Physiologyen_US
dc.subject.meshVasoconstrictionen_US
dc.titleInhibitory role of the endothelium in the response of isolated coronary arteries to plateletsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.6574604-
dc.identifier.pmid6574604-
dc.identifier.scopuseid_2-s2.0-0020576969en_US
dc.identifier.volume221en_US
dc.identifier.issue4607en_US
dc.identifier.spage273en_US
dc.identifier.epage274en_US
dc.identifier.isiWOS:A1983QX45300032-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCohen, RA=35562815800en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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