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Article: Calcium and α-adrenoceptors in activation of vascular smooth muscle

TitleCalcium and α-adrenoceptors in activation of vascular smooth muscle
Authors
Issue Date1982
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1982, v. 4 Suppl. 3, p. S280-S286 How to Cite?
AbstractCalcium entry blockers have differing effects on various vascular smooth muscle preparations during α-adrenoceptor activation. One possible explanation for these differences is that norepinephrine activates different subtypes of postjunctional α-adrenoceptors, which are linked preferentially to either the entry to extracellular or the mobilization of intracellular calcium. Therefore, differences in the sensitivity to calcium entry blockers during vasoconstrictor responses to exogenous or circulating catecholamines or to sympathetic nerve stimulation may reflect the heterogeneous pharmacological properties of the postjunctional α-adrenoceptors involved. However, depending on the blood vessel or the species studied, equally convincing evidence favoring the interpretation that either α1- or α2-adrenoceptors modulate the entry of extracellular calcium in vascular smooth muscle can be obtained. Therefore, it seems reasonable to conclude that the varying degrees of dependency of α-adrenoceptor activation on calcium entry are determined by the functional differentiation of the vascular smooth muscle cells rather than by the apparent pharmacological characteristics of their α-adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/170688
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorRimele, TJen_US
dc.date.accessioned2012-10-30T06:10:26Z-
dc.date.available2012-10-30T06:10:26Z-
dc.date.issued1982en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1982, v. 4 Suppl. 3, p. S280-S286en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170688-
dc.description.abstractCalcium entry blockers have differing effects on various vascular smooth muscle preparations during α-adrenoceptor activation. One possible explanation for these differences is that norepinephrine activates different subtypes of postjunctional α-adrenoceptors, which are linked preferentially to either the entry to extracellular or the mobilization of intracellular calcium. Therefore, differences in the sensitivity to calcium entry blockers during vasoconstrictor responses to exogenous or circulating catecholamines or to sympathetic nerve stimulation may reflect the heterogeneous pharmacological properties of the postjunctional α-adrenoceptors involved. However, depending on the blood vessel or the species studied, equally convincing evidence favoring the interpretation that either α1- or α2-adrenoceptors modulate the entry of extracellular calcium in vascular smooth muscle can be obtained. Therefore, it seems reasonable to conclude that the varying degrees of dependency of α-adrenoceptor activation on calcium entry are determined by the functional differentiation of the vascular smooth muscle cells rather than by the apparent pharmacological characteristics of their α-adrenoceptors.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshDiltiazem - Pharmacologyen_US
dc.subject.meshGallopamil - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Physiologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleCalcium and α-adrenoceptors in activation of vascular smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6184553-
dc.identifier.scopuseid_2-s2.0-0020434502en_US
dc.identifier.volume4en_US
dc.identifier.issueSuppl. 3en_US
dc.identifier.spageS280en_US
dc.identifier.epageS286en_US
dc.identifier.isiWOS:A1982PU96000004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridRimele, TJ=7004614618en_US

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