File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468)

TitleInteraction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468)
Authors
Issue Date1982
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1982, v. 77 n. 4, p. 281-287 How to Cite?
AbstractExperiments were designed to determine whether or not ketanserin (R 41 468) antagonizes the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non-adrenergic vasoconstrictor substances. Rings of rabbit femoral arteries were studied under isometric conditions in organ chambers filled with Krebs-Henseleit solution (37°C). Ketanserin, unlike methylsergide and LSD, was devoid of agonistic properties. It competitively antagonized contractile responses to 5-hydroxytryptamine and, at higher concentrations, to histamine. 5-Hydroxytryptamine amplified the contractions evoked by threshold concentrations of histamine, angiotensin II and prostaglandin F(2α); in all three cases, the amplification was antagonized by comparable concentrations of ketanserin. These experiments indicate that the interaction of 5-hydroxytryptamine with S2-receptors of the vascular smooth muscle cells is essential to allow the expression of the monoamine-induced amplification of the response to other vasoconstrictor substances. The inhibition by ketanserin of the amplifying effect of 5-hydroxytryptamine on vascular responses may help explain the antihypertensive properties of the compound.
Persistent Identifierhttp://hdl.handle.net/10722/170675
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorJanssen, PAJen_US
dc.contributor.authorDe Ridder, Wen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:24Z-
dc.date.available2012-10-30T06:10:24Z-
dc.date.issued1982en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1982, v. 77 n. 4, p. 281-287en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170675-
dc.description.abstractExperiments were designed to determine whether or not ketanserin (R 41 468) antagonizes the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non-adrenergic vasoconstrictor substances. Rings of rabbit femoral arteries were studied under isometric conditions in organ chambers filled with Krebs-Henseleit solution (37°C). Ketanserin, unlike methylsergide and LSD, was devoid of agonistic properties. It competitively antagonized contractile responses to 5-hydroxytryptamine and, at higher concentrations, to histamine. 5-Hydroxytryptamine amplified the contractions evoked by threshold concentrations of histamine, angiotensin II and prostaglandin F(2α); in all three cases, the amplification was antagonized by comparable concentrations of ketanserin. These experiments indicate that the interaction of 5-hydroxytryptamine with S2-receptors of the vascular smooth muscle cells is essential to allow the expression of the monoamine-induced amplification of the response to other vasoconstrictor substances. The inhibition by ketanserin of the amplifying effect of 5-hydroxytryptamine on vascular responses may help explain the antihypertensive properties of the compound.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEvoked Potentials - Drug Effectsen_US
dc.subject.meshFemoral Artery - Drug Effectsen_US
dc.subject.meshKetanserinen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshVasoconstrictor Agents - Pharmacologyen_US
dc.titleInteraction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468)en_US
dc.typeArticleen_US
dc.identifier.emailVanHoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanHoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(82)90130-3-
dc.identifier.pmid7060640-
dc.identifier.scopuseid_2-s2.0-0020048414en_US
dc.identifier.volume77en_US
dc.identifier.issue4en_US
dc.identifier.spage281en_US
dc.identifier.epage287en_US
dc.identifier.isiWOS:A1982ND19600010-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridJanssen, PAJ=36042383000en_US
dc.identifier.scopusauthoridDe Ridder, W=6602324543en_US
dc.identifier.scopusauthoridVanHoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats