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Article: Calcium entry blockers and vascular smooth muscle heterogeneity

TitleCalcium entry blockers and vascular smooth muscle heterogeneity
Authors
Issue Date1981
Citation
Federation Proceedings, 1981, v. 40 n. 14, p. 2862-2865 How to Cite?
AbstractInasmuch as the cytoplasmic level of activator Ca2+ governs the contractile activity of vascular smooth muscle cells, the efficacy of calcium entry blockers in curtailing vasoconstriction is determined by the dependency of this level on the influx of extracellular Ca2+ into the cells; this dependency varies with the trigger to contraction as well as with the anatomical origin of the vascular preparation tested. Certain calcium entry blockers (e.g. flunarizine and lidoflazine) tested in experimental conditions triggering the influx of the activator ion exhibit a pronounced tissue selectivity, presumably because the characteristics and accessibility of the Ca2+ channels vary among different vascular smooth muscle cells. The time of onset and duration of calcium entry blockade are not identical for all calcium entry blockers, which must reflect their permeation in the tissue as well as their individual pharmacological properties at the molecular level.
Persistent Identifierhttp://hdl.handle.net/10722/170656
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:18Z-
dc.date.available2012-10-30T06:10:18Z-
dc.date.issued1981en_US
dc.identifier.citationFederation Proceedings, 1981, v. 40 n. 14, p. 2862-2865en_US
dc.identifier.issn0014-9446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170656-
dc.description.abstractInasmuch as the cytoplasmic level of activator Ca2+ governs the contractile activity of vascular smooth muscle cells, the efficacy of calcium entry blockers in curtailing vasoconstriction is determined by the dependency of this level on the influx of extracellular Ca2+ into the cells; this dependency varies with the trigger to contraction as well as with the anatomical origin of the vascular preparation tested. Certain calcium entry blockers (e.g. flunarizine and lidoflazine) tested in experimental conditions triggering the influx of the activator ion exhibit a pronounced tissue selectivity, presumably because the characteristics and accessibility of the Ca2+ channels vary among different vascular smooth muscle cells. The time of onset and duration of calcium entry blockade are not identical for all calcium entry blockers, which must reflect their permeation in the tissue as well as their individual pharmacological properties at the molecular level.en_US
dc.languageengen_US
dc.relation.ispartofFederation Proceedingsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshCinnarizine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshFlunarizineen_US
dc.subject.meshGallopamil - Pharmacologyen_US
dc.subject.meshLidoflazine - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNifedipine - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleCalcium entry blockers and vascular smooth muscle heterogeneityen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7308496-
dc.identifier.scopuseid_2-s2.0-0019807129en_US
dc.identifier.volume40en_US
dc.identifier.issue14en_US
dc.identifier.spage2862en_US
dc.identifier.epage2865en_US
dc.identifier.isiWOS:A1981MU92400015-
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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