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Article: Cocaine and contractile responses of vascular smooth muscle from spontaneously hypertensive rats

TitleCocaine and contractile responses of vascular smooth muscle from spontaneously hypertensive rats
Authors
Issue Date1981
Citation
Archives Internationales De Pharmacodynamie Et De Therapie, 1981, v. 253 n. 2, p. 241-256 How to Cite?
AbstractThe goal of this study was to compare the effects of cocaine on contractile responses of isolated vascular smooth muscle from spontaneously hypertensive (SHR) and normotensive rats. Helical strips of tail artery from adult SHR and normotensive rats were mounted in organ chambers between two platinum wire electrodes; isometric contractions were recorded. Vascular responsiveness was determined before and after acute denervation with 6-hydroxydopamine or before and after treatment with cocaine. Cumulative addition of cocaine (10 -10 to 10 -3 M) produced contraction of the strips. SHR was found to be less sensitive to cocaine than normotensive rats. Contractions induced by cocaine were blocked by phentolamine and reduced after acute denervation. The sensitivity to exogenous norepinephrine (3 X 10 -12 to 3 X 10 -5 M) and contractile responses to electrical stimulation (0.1 to 16 Hz) of innervated strips were similar for SHR and normotensive rats. Cocaine (10 -6 M) potentiated contractile responses to norepinephrine and electrical stimulation. The magnitude of potentiation to norepinephrine and to electrical stimulation was greater in SHR than in normotensive rats. Cocaine (10 -6 M) produced relaxation of strips contracted with tyramine (10 -4 M). The magnitude of relaxation induced by cocaine was less in SHR than in normotensive rats. The uptake of 3H-norepinephrine was greater in tail arteries isolated from SHR as compared to those from normotensive rats. Cocaine (10 -4 M) inhibited the uptake of 3H-norepinephrine in both groups of rats. The magnitude of inhibition was greater in SHR. These results suggest that the neuronal uptake pump in blood vessels from SHR is more efficient than that in normotensive rats.
Persistent Identifierhttp://hdl.handle.net/10722/170655
ISSN
1998 Impact Factor: 0.72
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWebb, RCen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:18Z-
dc.date.available2012-10-30T06:10:18Z-
dc.date.issued1981en_US
dc.identifier.citationArchives Internationales De Pharmacodynamie Et De Therapie, 1981, v. 253 n. 2, p. 241-256en_US
dc.identifier.issn0003-9780en_US
dc.identifier.urihttp://hdl.handle.net/10722/170655-
dc.description.abstractThe goal of this study was to compare the effects of cocaine on contractile responses of isolated vascular smooth muscle from spontaneously hypertensive (SHR) and normotensive rats. Helical strips of tail artery from adult SHR and normotensive rats were mounted in organ chambers between two platinum wire electrodes; isometric contractions were recorded. Vascular responsiveness was determined before and after acute denervation with 6-hydroxydopamine or before and after treatment with cocaine. Cumulative addition of cocaine (10 -10 to 10 -3 M) produced contraction of the strips. SHR was found to be less sensitive to cocaine than normotensive rats. Contractions induced by cocaine were blocked by phentolamine and reduced after acute denervation. The sensitivity to exogenous norepinephrine (3 X 10 -12 to 3 X 10 -5 M) and contractile responses to electrical stimulation (0.1 to 16 Hz) of innervated strips were similar for SHR and normotensive rats. Cocaine (10 -6 M) potentiated contractile responses to norepinephrine and electrical stimulation. The magnitude of potentiation to norepinephrine and to electrical stimulation was greater in SHR than in normotensive rats. Cocaine (10 -6 M) produced relaxation of strips contracted with tyramine (10 -4 M). The magnitude of relaxation induced by cocaine was less in SHR than in normotensive rats. The uptake of 3H-norepinephrine was greater in tail arteries isolated from SHR as compared to those from normotensive rats. Cocaine (10 -4 M) inhibited the uptake of 3H-norepinephrine in both groups of rats. The magnitude of inhibition was greater in SHR. These results suggest that the neuronal uptake pump in blood vessels from SHR is more efficient than that in normotensive rats.en_US
dc.languageengen_US
dc.relation.ispartofArchives Internationales de Pharmacodynamie et de Therapieen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCocaine - Pharmacologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Metabolism - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleCocaine and contractile responses of vascular smooth muscle from spontaneously hypertensive ratsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7325762-
dc.identifier.scopuseid_2-s2.0-0019805582en_US
dc.identifier.volume253en_US
dc.identifier.issue2en_US
dc.identifier.spage241en_US
dc.identifier.epage256en_US
dc.identifier.isiWOS:A1981MT31100007-
dc.identifier.scopusauthoridWebb, RC=6603072737en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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