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Article: Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries

TitleRole of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries
Authors
Issue Date1981
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
Journal Of Physiology, 1981, v. Vol. 316, p. 347-355 How to Cite?
AbstractExperiments were designed to determine the role of the endothelium in relaxations of isolated blood vessels caused by ACh, adenine nucleotides and K+ ions. Paired rings of canine femoral arteries were mounted for isometric tension recording in organ chambers filled with aerated Krebs-Ringer solution (37°C). One ring served as control; in the other ring the intimal layer was removed mechanically. Removal of the endothelium only slightly depressed the maximal contractile response to noradrenaline, and did not affect the apparent sensitivity to the catecholamine. It depressed the contractile response to 25-60 mM-K+ more than that to noradrenaline. In the absence of endothelium, the femoral arteries did not relax on exposure to ACh. Removal of the endothelium did not affect relaxations caused by adenosine and AMP, but markedly reduced those caused by ADP and ATP. The relaxations induced by 5.9 mM-K+ were comparable in control rings and arteries denuded of their endothelium. These experiments demonstrate that in the canine femoral artery, relaxations induced by ACh, ADP and ATP require the presence of functional endothelial cells, which, when exposed to these substances, initiate an inhibitory signal for the smooth muscle cells of the media. By contrast, relaxations of isolated arteries caused by adenosine, AMP and K+ ions must be due mainly to a direct effect on the vascular smooth muscle cells.
Persistent Identifierhttp://hdl.handle.net/10722/170649
ISSN
2015 Impact Factor: 4.731
2015 SCImago Journal Rankings: 2.670
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDe Mey, JGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:17Z-
dc.date.available2012-10-30T06:10:17Z-
dc.date.issued1981en_US
dc.identifier.citationJournal Of Physiology, 1981, v. Vol. 316, p. 347-355en_US
dc.identifier.issn0022-3751en_US
dc.identifier.urihttp://hdl.handle.net/10722/170649-
dc.description.abstractExperiments were designed to determine the role of the endothelium in relaxations of isolated blood vessels caused by ACh, adenine nucleotides and K+ ions. Paired rings of canine femoral arteries were mounted for isometric tension recording in organ chambers filled with aerated Krebs-Ringer solution (37°C). One ring served as control; in the other ring the intimal layer was removed mechanically. Removal of the endothelium only slightly depressed the maximal contractile response to noradrenaline, and did not affect the apparent sensitivity to the catecholamine. It depressed the contractile response to 25-60 mM-K+ more than that to noradrenaline. In the absence of endothelium, the femoral arteries did not relax on exposure to ACh. Removal of the endothelium did not affect relaxations caused by adenosine and AMP, but markedly reduced those caused by ADP and ATP. The relaxations induced by 5.9 mM-K+ were comparable in control rings and arteries denuded of their endothelium. These experiments demonstrate that in the canine femoral artery, relaxations induced by ACh, ADP and ATP require the presence of functional endothelial cells, which, when exposed to these substances, initiate an inhibitory signal for the smooth muscle cells of the media. By contrast, relaxations of isolated arteries caused by adenosine, AMP and K+ ions must be due mainly to a direct effect on the vascular smooth muscle cells.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751en_US
dc.relation.ispartofJournal of Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAdenine Nucleotides - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium - Physiologyen_US
dc.subject.meshFemoral Artery - Physiologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshReceptors, Cholinergic - Physiologyen_US
dc.titleRole of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7320872-
dc.identifier.scopuseid_2-s2.0-0019732146en_US
dc.identifier.volumeVol. 316en_US
dc.identifier.spage347en_US
dc.identifier.epage355en_US
dc.identifier.isiWOS:A1981LZ11100026-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridDe Mey, JG=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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