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Article: Effect of removal and substitution of potassium ions on the adrenergic and cholinergic reactivity in canine femoral artery.

TitleEffect of removal and substitution of potassium ions on the adrenergic and cholinergic reactivity in canine femoral artery.
Authors
De Mey, JVanhoutte, PM
KeywordsAcetycholine
Femoral artery
Hyperpolarisation
Na+, K+ATPase
Origin of activator Ca+
Potassium
Issue Date1980
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1980, v. 67 n. 1, p. 159-164 How to Cite?
DOI: http://dx.doi.org/10.1016/0014-2999(80)90027-8
AbstractCanine femoral arteries responded to acetylcholine with relaxations; these were abolished in potassium free solution, restored by potassium or rubidium but not by cesium or amonium. Potassium and rubidium were equipotent in inducing ouabain-sensitive relaxation, while amonium and cesium were less potent. The results (1) confirm that sodium-potassium exchanges are indirectly involved in cholinergic relaxation of arterial smooth muscle and (2) suggest that membrane hyperpolarisation resulting from increased electrogenic sodium transport does not affect the inhibitory response to the cholinergic transmitter.
Persistent Identifierhttp://hdl.handle.net/10722/170624
ISSN
0014-2999
2021 Impact Factor: 5.195
2020 SCImago Journal Rankings: 1.046
ISI Accession Number ID
WOS:A1980KN43500026

 

DC FieldValueLanguage
dc.contributor.authorDe Mey, Jen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:11Z-
dc.date.available2012-10-30T06:10:11Z-
dc.date.issued1980en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1980, v. 67 n. 1, p. 159-164en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170624-
dc.description.abstractCanine femoral arteries responded to acetylcholine with relaxations; these were abolished in potassium free solution, restored by potassium or rubidium but not by cesium or amonium. Potassium and rubidium were equipotent in inducing ouabain-sensitive relaxation, while amonium and cesium were less potent. The results (1) confirm that sodium-potassium exchanges are indirectly involved in cholinergic relaxation of arterial smooth muscle and (2) suggest that membrane hyperpolarisation resulting from increased electrogenic sodium transport does not affect the inhibitory response to the cholinergic transmitter.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subjectAcetycholine-
dc.subjectFemoral artery-
dc.subjectHyperpolarisation-
dc.subjectNa+, K+ATPase-
dc.subjectOrigin of activator Ca+-
dc.subjectPotassium-
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshFemoral Artery - Drug Effectsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshSodium - Pharmacologyen_US
dc.titleEffect of removal and substitution of potassium ions on the adrenergic and cholinergic reactivity in canine femoral artery.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(80)90027-8en_US
dc.identifier.pmid7418730-
dc.identifier.scopuseid_2-s2.0-0019316007en_US
dc.identifier.volume67en_US
dc.identifier.issue1en_US
dc.identifier.spage159en_US
dc.identifier.epage164en_US
dc.identifier.isiWOS:A1980KN43500026-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridDe Mey, J=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0014-2999-

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