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Article: Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system.

TitlePrejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system.
Authors
Issue Date1980
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1980, v. 238 n. 3, p. H275-281 How to Cite?
AbstractIn the heart and in the blood vessel walls, complex adrenergic-cholinergic interactions occur both prejunctionally, at the level of the autonomic nerve terminals, and postjunctionally, at the level of the responding cells themselves. The principal prejunctional interaction appears to be an inhibition of the release of norepinephrine from adrenergic nerve terminals by the acetylcholine liberated from nearby cholinergic nerve endings. This inhibitory effect is mediated by muscarinic receptors located on the postganglionic sympathetic nerve terminals. The inhibitory effect of acetylcholine on cardiac and vascular tissues are therefore achieved in part by a direct influence of the cholinergic neurotransmitter on the cardiac and vascular muscle cells, and in part by an indirect influence on sympathetic neurotransmission.
Persistent Identifierhttp://hdl.handle.net/10722/170607
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorLevy, MNen_US
dc.date.accessioned2012-10-30T06:10:07Z-
dc.date.available2012-10-30T06:10:07Z-
dc.date.issued1980en_US
dc.identifier.citationThe American Journal Of Physiology, 1980, v. 238 n. 3, p. H275-281en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170607-
dc.description.abstractIn the heart and in the blood vessel walls, complex adrenergic-cholinergic interactions occur both prejunctionally, at the level of the autonomic nerve terminals, and postjunctionally, at the level of the responding cells themselves. The principal prejunctional interaction appears to be an inhibition of the release of norepinephrine from adrenergic nerve terminals by the acetylcholine liberated from nearby cholinergic nerve endings. This inhibitory effect is mediated by muscarinic receptors located on the postganglionic sympathetic nerve terminals. The inhibitory effect of acetylcholine on cardiac and vascular tissues are therefore achieved in part by a direct influence of the cholinergic neurotransmitter on the cardiac and vascular muscle cells, and in part by an indirect influence on sympathetic neurotransmission.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAcetylcholine - Pharmacology - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiovascular Physiological Phenomenaen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshEpinephrine - Pharmacology - Physiologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeart - Innervationen_US
dc.subject.meshMuscle Tonusen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshMyocardial Contraction - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacology - Physiologyen_US
dc.subject.meshParasympathetic Nervous System - Physiologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.subject.meshSympathetic Nervous System - Physiologyen_US
dc.subject.meshSynaptic Transmissionen_US
dc.subject.meshVasomotor System - Drug Effectsen_US
dc.titlePrejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6245589-
dc.identifier.scopuseid_2-s2.0-0018988984en_US
dc.identifier.volume238en_US
dc.identifier.issue3en_US
dc.identifier.spageH275en_US
dc.identifier.epage281en_US
dc.identifier.isiWOS:A1980JK26800042-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridLevy, MN=7404617009en_US

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