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- Scopus: eid_2-s2.0-0018988984
- PMID: 6245589
- WOS: WOS:A1980JK26800042
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Article: Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system.
Title | Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system. |
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Authors | |
Issue Date | 1980 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | The American Journal Of Physiology, 1980, v. 238 n. 3, p. H275-281 How to Cite? |
Abstract | In the heart and in the blood vessel walls, complex adrenergic-cholinergic interactions occur both prejunctionally, at the level of the autonomic nerve terminals, and postjunctionally, at the level of the responding cells themselves. The principal prejunctional interaction appears to be an inhibition of the release of norepinephrine from adrenergic nerve terminals by the acetylcholine liberated from nearby cholinergic nerve endings. This inhibitory effect is mediated by muscarinic receptors located on the postganglionic sympathetic nerve terminals. The inhibitory effect of acetylcholine on cardiac and vascular tissues are therefore achieved in part by a direct influence of the cholinergic neurotransmitter on the cardiac and vascular muscle cells, and in part by an indirect influence on sympathetic neurotransmission. |
Persistent Identifier | http://hdl.handle.net/10722/170607 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Levy, MN | en_US |
dc.date.accessioned | 2012-10-30T06:10:07Z | - |
dc.date.available | 2012-10-30T06:10:07Z | - |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | The American Journal Of Physiology, 1980, v. 238 n. 3, p. H275-281 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170607 | - |
dc.description.abstract | In the heart and in the blood vessel walls, complex adrenergic-cholinergic interactions occur both prejunctionally, at the level of the autonomic nerve terminals, and postjunctionally, at the level of the responding cells themselves. The principal prejunctional interaction appears to be an inhibition of the release of norepinephrine from adrenergic nerve terminals by the acetylcholine liberated from nearby cholinergic nerve endings. This inhibitory effect is mediated by muscarinic receptors located on the postganglionic sympathetic nerve terminals. The inhibitory effect of acetylcholine on cardiac and vascular tissues are therefore achieved in part by a direct influence of the cholinergic neurotransmitter on the cardiac and vascular muscle cells, and in part by an indirect influence on sympathetic neurotransmission. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | The American Journal Of Physiology | en_US |
dc.subject.mesh | Acetylcholine - Pharmacology - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cardiovascular Physiological Phenomena | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Epinephrine - Pharmacology - Physiology | en_US |
dc.subject.mesh | Guinea Pigs | en_US |
dc.subject.mesh | Heart - Innervation | en_US |
dc.subject.mesh | Muscle Tonus | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiology | en_US |
dc.subject.mesh | Myocardial Contraction - Drug Effects | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology - Physiology | en_US |
dc.subject.mesh | Parasympathetic Nervous System - Physiology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Sympathetic Nervous System - Physiology | en_US |
dc.subject.mesh | Synaptic Transmission | en_US |
dc.subject.mesh | Vasomotor System - Drug Effects | en_US |
dc.title | Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 6245589 | - |
dc.identifier.scopus | eid_2-s2.0-0018988984 | en_US |
dc.identifier.volume | 238 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | H275 | en_US |
dc.identifier.epage | 281 | en_US |
dc.identifier.isi | WOS:A1980JK26800042 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Levy, MN=7404617009 | en_US |
dc.identifier.issnl | 0002-9513 | - |