File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Interaction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen

TitleInteraction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen
Authors
Issue Date1979
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
Blood Vessels, 1979, v. 16 n. 3, p. 113-125 How to Cite?
AbstractExperiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional α-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and portal and saphenous veins were labeled with 7-3H-norepinephrine and mounted for superfusion. In the portal vein, an inhibitory effect of prejunctional receptor activation with exogenous norepinephrine (1.2 x 10-6M) on transmitter efflux could be demonstrated during electrical stimulation (9 V, 2 Hz) of the nerve terminals. By contrast, in the other tissues, inhibition of transmitter release during electrical stimulation or depolarization of the nerve terminals with K+ (40 mEq/1) could only be demonstrated after blockade of the neuronal uptake mechanism. That activation of prejunctional α-adrenergic receptors in blood vessels inhibits the exocytotic process is suggested by the failure of exogenous norepinephrine to affect either the basal efflux of 3H-norepinephrine or the displacement of 3H-norepinephrine by tyramine.
Persistent Identifierhttp://hdl.handle.net/10722/170596
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLorenz, RRen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorShepherd, JTen_US
dc.date.accessioned2012-10-30T06:10:05Z-
dc.date.available2012-10-30T06:10:05Z-
dc.date.issued1979en_US
dc.identifier.citationBlood Vessels, 1979, v. 16 n. 3, p. 113-125en_US
dc.identifier.issn0303-6847en_US
dc.identifier.urihttp://hdl.handle.net/10722/170596-
dc.description.abstractExperiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional α-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and portal and saphenous veins were labeled with 7-3H-norepinephrine and mounted for superfusion. In the portal vein, an inhibitory effect of prejunctional receptor activation with exogenous norepinephrine (1.2 x 10-6M) on transmitter efflux could be demonstrated during electrical stimulation (9 V, 2 Hz) of the nerve terminals. By contrast, in the other tissues, inhibition of transmitter release during electrical stimulation or depolarization of the nerve terminals with K+ (40 mEq/1) could only be demonstrated after blockade of the neuronal uptake mechanism. That activation of prejunctional α-adrenergic receptors in blood vessels inhibits the exocytotic process is suggested by the failure of exogenous norepinephrine to affect either the basal efflux of 3H-norepinephrine or the displacement of 3H-norepinephrine by tyramine.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVRen_US
dc.relation.ispartofBlood Vesselsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Abdominal - Innervationen_US
dc.subject.meshBlood Vessels - Drug Effects - Innervation - Metabolismen_US
dc.subject.meshChromatographyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMesenteric Arteries - Innervationen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effects - Innervation - Metabolismen_US
dc.subject.meshNeuromuscular Junction - Drug Effectsen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshNorepinephrine - Metabolism - Pharmacologyen_US
dc.subject.meshPhenoxybenzamine - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Drug Effectsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effectsen_US
dc.subject.meshSaphenous Vein - Innervationen_US
dc.subject.meshSplenic Artery - Innervationen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.titleInteraction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleenen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid221058-
dc.identifier.scopuseid_2-s2.0-0018757797en_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.spage113en_US
dc.identifier.epage125en_US
dc.identifier.isiWOS:A1979HB03700001-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLorenz, RR=7402095192en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats