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Article: Interaction between alpha adrenergic and serotonergic activation of canine saphenous veins

TitleInteraction between alpha adrenergic and serotonergic activation of canine saphenous veins
Authors
Issue Date1978
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1978, v. 207 n. 3, p. 936-949 How to Cite?
AbstractSerotonin and norepinephrine produced concentration-dependent contractions of helical strips of canine saphenous veins. The contractile responses to both agonists were inhibited by the alpha adrenergic receptor blocking agent phentolamine. Tolazoline inhibited the contractile responses of canine saphenous veins to norepinephrine but augmented those to serotonin. Blockade of adrenergic neuronal reuptake with cocaine enhanced the sensitivity of the canine saphenous vein to serotonin, but did not suppress the inhibition by phentolamine of the contractile responses to this indolealkylamine. Serotonin-mediated venoconstriction was not secondary to release of norepinephrine since it was not accompanied by an increased release of [7-3H]-norepinephrine. These findings suggest that serotonin does not contract canine saphenous veins by stimulation of typical serotonergic receptors. The binding sites for serotonin and norepinephrine in cutaneous venous smooth muscle may share part of a common receptor complex, which triggers the contractile process. Alternatively, serotonin and norepinephrine may act at two different receptors to elicit contraction of canine saphenous veins.
Persistent Identifierhttp://hdl.handle.net/10722/170565
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCurro, FAen_US
dc.contributor.authorGreenberg, Sen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:58Z-
dc.date.available2012-10-30T06:09:58Z-
dc.date.issued1978en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1978, v. 207 n. 3, p. 936-949en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170565-
dc.description.abstractSerotonin and norepinephrine produced concentration-dependent contractions of helical strips of canine saphenous veins. The contractile responses to both agonists were inhibited by the alpha adrenergic receptor blocking agent phentolamine. Tolazoline inhibited the contractile responses of canine saphenous veins to norepinephrine but augmented those to serotonin. Blockade of adrenergic neuronal reuptake with cocaine enhanced the sensitivity of the canine saphenous vein to serotonin, but did not suppress the inhibition by phentolamine of the contractile responses to this indolealkylamine. Serotonin-mediated venoconstriction was not secondary to release of norepinephrine since it was not accompanied by an increased release of [7-3H]-norepinephrine. These findings suggest that serotonin does not contract canine saphenous veins by stimulation of typical serotonergic receptors. The binding sites for serotonin and norepinephrine in cutaneous venous smooth muscle may share part of a common receptor complex, which triggers the contractile process. Alternatively, serotonin and norepinephrine may act at two different receptors to elicit contraction of canine saphenous veins.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCocaine - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshHydrocortisone - Pharmacologyen_US
dc.subject.meshMethysergide - Pharmacologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Drug Effectsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effectsen_US
dc.subject.meshSaphenous Vein - Drug Effectsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshTolazoline - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVeins - Drug Effectsen_US
dc.titleInteraction between alpha adrenergic and serotonergic activation of canine saphenous veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid215746-
dc.identifier.scopuseid_2-s2.0-0018237743en_US
dc.identifier.volume207en_US
dc.identifier.issue3en_US
dc.identifier.spage936en_US
dc.identifier.epage949en_US
dc.identifier.isiWOS:A1978GF98100030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCurro, FA=7004554859en_US
dc.identifier.scopusauthoridGreenberg, S=7402294616en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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