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Article: Effect of prostacyclin on myogenic activity and adrenergic neuroeffector interaction in canine isolated veins

TitleEffect of prostacyclin on myogenic activity and adrenergic neuroeffector interaction in canine isolated veins
Authors
Issue Date1978
Citation
Prostaglandins, 1978, v. 16 n. 6, p. 911-921 How to Cite?
AbstractIn isolated strips of canine mesenteric vein prostacyclin (PGI2) causes a dose-dependent depression of the amplitude of the spontaneous rhythmic contractions without influencing their frequency. This suggests that prostacyclin affects the events leading from the depolarization of the smooth muscle cells to their contractions, rather than the induction of the myogenic activity itself. Furthermore, prostacyclin reduces the noradrenaline-induced contraction of the canine saphenous vein without affecting the electrically induced responses, suggesting a possible dual effect of the drug: at the smooth muscle it causes depression of the responsiveness to noradrenaline whereas at the adrenergic nerve endings it enhances the evoked release of the adrenergic transmitter.
Persistent Identifierhttp://hdl.handle.net/10722/170560
ISSN
2004 Impact Factor: 3.588
2000 SCImago Journal Rankings: 0.996
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHerman, AGen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorMoncada, Sen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:57Z-
dc.date.available2012-10-30T06:09:57Z-
dc.date.issued1978en_US
dc.identifier.citationProstaglandins, 1978, v. 16 n. 6, p. 911-921en_US
dc.identifier.issn0090-6980en_US
dc.identifier.urihttp://hdl.handle.net/10722/170560-
dc.description.abstractIn isolated strips of canine mesenteric vein prostacyclin (PGI2) causes a dose-dependent depression of the amplitude of the spontaneous rhythmic contractions without influencing their frequency. This suggests that prostacyclin affects the events leading from the depolarization of the smooth muscle cells to their contractions, rather than the induction of the myogenic activity itself. Furthermore, prostacyclin reduces the noradrenaline-induced contraction of the canine saphenous vein without affecting the electrically induced responses, suggesting a possible dual effect of the drug: at the smooth muscle it causes depression of the responsiveness to noradrenaline whereas at the adrenergic nerve endings it enhances the evoked release of the adrenergic transmitter.en_US
dc.languageengen_US
dc.relation.ispartofProstaglandinsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshEpoprostenol - Pharmacologyen_US
dc.subject.meshMesenteric Veins - Drug Effects - Innervationen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effects - Innervationen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshProstaglandins - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Drug Effectsen_US
dc.subject.meshSaphenous Vein - Drug Effects - Innervationen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.subject.meshVeins - Drug Effectsen_US
dc.titleEffect of prostacyclin on myogenic activity and adrenergic neuroeffector interaction in canine isolated veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0090-6980(78)90106-5-
dc.identifier.pmid219444-
dc.identifier.scopuseid_2-s2.0-0018216806en_US
dc.identifier.volume16en_US
dc.identifier.issue6en_US
dc.identifier.spage911en_US
dc.identifier.epage921en_US
dc.identifier.isiWOS:A1978GG28600006-
dc.identifier.scopusauthoridHerman, AG=7202683471en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridMoncada, S=7202884383en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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