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Article: Instantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins.

TitleInstantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins.
Authors
Issue Date1978
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1978, v. 234 n. 4, p. H330-337 How to Cite?
AbstractExperiments were performed to investigate why cooling augments the contractile responses of superficial veins, but depresses that of deep limb veins. Rings of dog's saphenous veins were mounted in an organ chamber for isometric tension recording. Cooling (from 37 to 24 degrees C) depressed the tissular uptake of [3H]norepinephrine and potentiated the contraction caused by norepinephrine and sympathetic nerve stimulation; this potentiation persisted after inhibition of the disposition mechanisms for the catecholamine and in the presence of ouabain or iproveratril. The affinity of the alpha adrenoceptors, to judge from the KA values for norepinephrine and from the pA2 values for the competitive antagonist phentolamine, was significantly greater at 24 degrees C than at 37 degrees C. Thus, an instantaneous change in the affinity of alpha adrenoceptors explains the augmented response of the cutaneous veins to adrenergic stimulation. By contrast, cooling depressed the response of femoral veins to norepinephrine and did not significantly affect the affinity of alpha adrenoceptors in this preparation, indicating that the temperature sensitivity of alpha adrenoceptors in cutaneous veins is related to chronic exposure to variations in local temperature.
Persistent Identifierhttp://hdl.handle.net/10722/170555
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJanssens, WJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:54Z-
dc.date.available2012-10-30T06:09:54Z-
dc.date.issued1978en_US
dc.identifier.citationThe American Journal Of Physiology, 1978, v. 234 n. 4, p. H330-337en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170555-
dc.description.abstractExperiments were performed to investigate why cooling augments the contractile responses of superficial veins, but depresses that of deep limb veins. Rings of dog's saphenous veins were mounted in an organ chamber for isometric tension recording. Cooling (from 37 to 24 degrees C) depressed the tissular uptake of [3H]norepinephrine and potentiated the contraction caused by norepinephrine and sympathetic nerve stimulation; this potentiation persisted after inhibition of the disposition mechanisms for the catecholamine and in the presence of ouabain or iproveratril. The affinity of the alpha adrenoceptors, to judge from the KA values for norepinephrine and from the pA2 values for the competitive antagonist phentolamine, was significantly greater at 24 degrees C than at 37 degrees C. Thus, an instantaneous change in the affinity of alpha adrenoceptors explains the augmented response of the cutaneous veins to adrenergic stimulation. By contrast, cooling depressed the response of femoral veins to norepinephrine and did not significantly affect the affinity of alpha adrenoceptors in this preparation, indicating that the temperature sensitivity of alpha adrenoceptors in cutaneous veins is related to chronic exposure to variations in local temperature.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Transport, Activeen_US
dc.subject.meshBody Temperature Regulationen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDogsen_US
dc.subject.meshEstradiol - Pharmacologyen_US
dc.subject.meshMuscle, Smooth - Metabolismen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshOuabain - Pharmacologyen_US
dc.subject.meshPargyline - Pharmacologyen_US
dc.subject.meshPhenoxybenzamine - Pharmacologyen_US
dc.subject.meshPotassium - Metabolismen_US
dc.subject.meshReceptors, Adrenergic - Metabolismen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Metabolismen_US
dc.subject.meshSkin - Blood Supply - Innervationen_US
dc.subject.meshSkin Temperatureen_US
dc.subject.meshSodium - Metabolismen_US
dc.subject.meshVasomotor System - Physiologyen_US
dc.subject.meshVeins - Metabolism - Physiologyen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleInstantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid206149-
dc.identifier.scopuseid_2-s2.0-0017958338en_US
dc.identifier.volume234en_US
dc.identifier.issue4en_US
dc.identifier.spageH330en_US
dc.identifier.epage337en_US
dc.identifier.isiWOS:A1978EW34100017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJanssens, WJ=7006876881en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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