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Article: Norepinephrine metabolism in canine saphenous vein: prevalence of glycol metabolites.

TitleNorepinephrine metabolism in canine saphenous vein: prevalence of glycol metabolites.
Authors
Issue Date1978
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1978, v. 234 n. 3, p. H235-243 How to Cite?
AbstractTo examine the disposition of [3H]norepinephrine ([3H]NE) in adrenergically innervated veins, helical strips of canine saphenous veins were incubated in Krebs-Ringer solution containing D,L[3H]NE (2 X 10(-7) M) for 2 h. [3H]NE and its metabolites were measured in extracts of veins and in superfusate (Krebs-Ringer) collected during basal conditions and during release of [3H]NE evoked by electrical stimulation (1-8 Hz), tyramine (5 X 10(-6) to 5 X 10(-4) M), or high concentrations of potassium (35-100 meq/liter). During basal conditions, the efflux from veins comprised mainly metabolits of [3H]NE, especially 3,4-dihydroxphenylglycol (DOPEG) and 3-methoxy-4-hydroxyphenylglycol (MOPEG); this pattern was unchanged by cocaine treatment, and monoamine oxidase inhibition reduced the formation of DOPEG. During evoked release of NE, the major metabolites in the perfusate were DOPEG, MOPEG, and normetanephrine, and their proportions differed with the stimulus used: O-methylated metabolites in the perfusate always increased more than did the deaminated catechol compounds; DOPEG and MOPEG were released in greater amounts than the corresponding acids; and cocaine treatment caused a higher content of all metabolites except DOPEG. 3-Methoxy-4-hydroxymandelic acid was also formed by the vein but was retained in the tissue.
Persistent Identifierhttp://hdl.handle.net/10722/170554
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMuldoon, SMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorTyce, GMen_US
dc.date.accessioned2012-10-30T06:09:54Z-
dc.date.available2012-10-30T06:09:54Z-
dc.date.issued1978en_US
dc.identifier.citationThe American Journal Of Physiology, 1978, v. 234 n. 3, p. H235-243en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170554-
dc.description.abstractTo examine the disposition of [3H]norepinephrine ([3H]NE) in adrenergically innervated veins, helical strips of canine saphenous veins were incubated in Krebs-Ringer solution containing D,L[3H]NE (2 X 10(-7) M) for 2 h. [3H]NE and its metabolites were measured in extracts of veins and in superfusate (Krebs-Ringer) collected during basal conditions and during release of [3H]NE evoked by electrical stimulation (1-8 Hz), tyramine (5 X 10(-6) to 5 X 10(-4) M), or high concentrations of potassium (35-100 meq/liter). During basal conditions, the efflux from veins comprised mainly metabolits of [3H]NE, especially 3,4-dihydroxphenylglycol (DOPEG) and 3-methoxy-4-hydroxyphenylglycol (MOPEG); this pattern was unchanged by cocaine treatment, and monoamine oxidase inhibition reduced the formation of DOPEG. During evoked release of NE, the major metabolites in the perfusate were DOPEG, MOPEG, and normetanephrine, and their proportions differed with the stimulus used: O-methylated metabolites in the perfusate always increased more than did the deaminated catechol compounds; DOPEG and MOPEG were released in greater amounts than the corresponding acids; and cocaine treatment caused a higher content of all metabolites except DOPEG. 3-Methoxy-4-hydroxymandelic acid was also formed by the vein but was retained in the tissue.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromatography, Ion Exchange - Methodsen_US
dc.subject.meshChromatography, Paperen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshGlycols - Analysis - Metabolismen_US
dc.subject.meshMandelic Acids - Metabolismen_US
dc.subject.meshMethoxyhydroxyphenylglycol - Metabolismen_US
dc.subject.meshMonoamine Oxidase - Metabolismen_US
dc.subject.meshNeural Inhibitionen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshNormetanephrine - Metabolismen_US
dc.subject.meshPargyline - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Analysis - Metabolismen_US
dc.subject.meshTyramine - Pharmacologyen_US
dc.subject.meshVanilmandelic Acid - Metabolismen_US
dc.titleNorepinephrine metabolism in canine saphenous vein: prevalence of glycol metabolites.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid629360-
dc.identifier.scopuseid_2-s2.0-0017946516en_US
dc.identifier.volume234en_US
dc.identifier.issue3en_US
dc.identifier.spageH235en_US
dc.identifier.epage243en_US
dc.identifier.isiWOS:A1978ES25600036-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMuldoon, SM=7006041150en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridTyce, GM=7004909546en_US

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