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Article: Depression by local cooling of 3H norepinephrine release evoked by nerve stimulation in cutaneous veins

TitleDepression by local cooling of 3H norepinephrine release evoked by nerve stimulation in cutaneous veins
Authors
Issue Date1976
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
Blood Vessels, 1976, v. 13 n. 1-2, p. 92-99 How to Cite?
AbstractExperiments were performed to investigate whether local cooling facilitates adrenergic neurotransmission in the cutaneous vein of the dog. Helical strips of saphenous veins were incubated with 3H norepinephrine and mounted for isometric tension recording and superfusion. The superfusate was collected for measurement of total radioactivity or for chromatographic analysis. Electrical stimulation (2Hz) caused contraction and augmented the efflux of 3H norepinephrine and metabolites. Cooling (from 37 to 28°C) imposed during electrical stimulation caused a further increase in tension, but decreased the amount of 3H norepinephrine and metabolites overflowing into the superfusate. These experiments demonstrate that the potentiating effect of cooling on the response of cutaneous veins to sympathetic nerve stimulation is not associated with facilitation of adrenergic neurotransmission. It probably is due to an altered sensitivity of the vascular smooth muscle to the transmitter.
Persistent Identifierhttp://hdl.handle.net/10722/170520
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorVerbeuren, TJen_US
dc.date.accessioned2012-10-30T06:09:47Z-
dc.date.available2012-10-30T06:09:47Z-
dc.date.issued1976en_US
dc.identifier.citationBlood Vessels, 1976, v. 13 n. 1-2, p. 92-99en_US
dc.identifier.issn0303-6847en_US
dc.identifier.urihttp://hdl.handle.net/10722/170520-
dc.description.abstractExperiments were performed to investigate whether local cooling facilitates adrenergic neurotransmission in the cutaneous vein of the dog. Helical strips of saphenous veins were incubated with 3H norepinephrine and mounted for isometric tension recording and superfusion. The superfusate was collected for measurement of total radioactivity or for chromatographic analysis. Electrical stimulation (2Hz) caused contraction and augmented the efflux of 3H norepinephrine and metabolites. Cooling (from 37 to 28°C) imposed during electrical stimulation caused a further increase in tension, but decreased the amount of 3H norepinephrine and metabolites overflowing into the superfusate. These experiments demonstrate that the potentiating effect of cooling on the response of cutaneous veins to sympathetic nerve stimulation is not associated with facilitation of adrenergic neurotransmission. It probably is due to an altered sensitivity of the vascular smooth muscle to the transmitter.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVRen_US
dc.relation.ispartofBlood Vesselsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromatographyen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth - Physiologyen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshSaphenous Vein - Innervation - Metabolismen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshVasomotor System - Physiologyen_US
dc.subject.meshVeins - Innervationen_US
dc.titleDepression by local cooling of 3H norepinephrine release evoked by nerve stimulation in cutaneous veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1247697-
dc.identifier.scopuseid_2-s2.0-0017254608en_US
dc.identifier.volume13en_US
dc.identifier.issue1-2en_US
dc.identifier.spage92en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:A1976BG19700007-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US

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