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Article: Effects of amide linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dog

TitleEffects of amide linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dog
Authors
Issue Date1976
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1976, v. 196 n. 3, p. 723-736 How to Cite?
AbstractWhen changes in isometric tension of helical strips of dog saphenous veins were recorded, etidocaine caused a dose dependent depression of the contractile responses to nerve stimulation, norepinephrine and K+. The response to nerve stimulation was significantly more depressed than that to exogenous norepinephrine. Similar results were obtained with lidocaine. In preparations incubated in solutions containing 3H norepinephrine and mounted for superfusion and isometric tension recording, etidocaine depressed the contractions and diminished the release of 3H norepinephrine evoked by nerve stimulation. Thus, in addition to an inhibitory effect on the responses of smooth muscle cells, amide linked local anesthetic agents such as etidocaine depress adrenergic neurotransmission in the blood vessel wall, which helps explain their vasodilator properties in the intact organism. In unstimulated preparations and during contractions caused by K+, etidocaine increased the efflux of 3H norepinephrine and deaminated metabolites. After incubation with the monoamine oxidase inhibitor, pargyline, etidocaine augmented markedly the efflux of 3H norepinephrine. During responses to tyramine, it augmented the release of 3H norepinephrine more than the efflux of deaminated compounds. This suggests that etidocaine augments the leakage of norepinephrine out of the storage vesicles, making more catecholamines available for intraneuronal deamination.
Persistent Identifierhttp://hdl.handle.net/10722/170519
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMuldoon, SMen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:47Z-
dc.date.available2012-10-30T06:09:47Z-
dc.date.issued1976en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1976, v. 196 n. 3, p. 723-736en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170519-
dc.description.abstractWhen changes in isometric tension of helical strips of dog saphenous veins were recorded, etidocaine caused a dose dependent depression of the contractile responses to nerve stimulation, norepinephrine and K+. The response to nerve stimulation was significantly more depressed than that to exogenous norepinephrine. Similar results were obtained with lidocaine. In preparations incubated in solutions containing 3H norepinephrine and mounted for superfusion and isometric tension recording, etidocaine depressed the contractions and diminished the release of 3H norepinephrine evoked by nerve stimulation. Thus, in addition to an inhibitory effect on the responses of smooth muscle cells, amide linked local anesthetic agents such as etidocaine depress adrenergic neurotransmission in the blood vessel wall, which helps explain their vasodilator properties in the intact organism. In unstimulated preparations and during contractions caused by K+, etidocaine increased the efflux of 3H norepinephrine and deaminated metabolites. After incubation with the monoamine oxidase inhibitor, pargyline, etidocaine augmented markedly the efflux of 3H norepinephrine. During responses to tyramine, it augmented the release of 3H norepinephrine more than the efflux of deaminated compounds. This suggests that etidocaine augments the leakage of norepinephrine out of the storage vesicles, making more catecholamines available for intraneuronal deamination.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAmides - Pharmacologyen_US
dc.subject.meshAnesthetics, Local - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshNeuroeffector Junction - Drug Effectsen_US
dc.subject.meshNorepinephrine - Metabolism - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Physiologyen_US
dc.subject.meshSympathetic Nervous System - Drug Effectsen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.subject.meshTyramine - Pharmacologyen_US
dc.titleEffects of amide linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid177755-
dc.identifier.scopuseid_2-s2.0-0017249672en_US
dc.identifier.volume196en_US
dc.identifier.issue3en_US
dc.identifier.spage723en_US
dc.identifier.epage736en_US
dc.identifier.isiWOS:A1976BM51100021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMuldoon, SM=7006041150en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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