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Article: Effects of anoxia and glucose depletion on isolated veins of the dog

TitleEffects of anoxia and glucose depletion on isolated veins of the dog
Authors
Issue Date1976
Citation
American Journal Of Physiology, 1976, v. 230 n. 5, p. 1261-1268 How to Cite?
AbstractCanine vein strips were mounted for isometric tension recording. Anoxia did not affect basal tension of saphenous and pulmonary strips mounted in standard Krebs Ringer solution or after 30 min of incubation in glucose free solution. Anoxia depressed the strength of spontaneous contractions of mesenteric veins; in glucose free solution (30 min), anoxia relaxed the strips. Veins placed in glucose free solution for more than 60 min contracted with anoxia; this contraction was not inhibited by iproveratril. When the vein strips were contracted by norepinephrine or KCl, anoxia depressed the contractions, most in mesenteric and least in saphenous preparations; this depression was greater in the absence of glucose. When oxygen was present, the absence of glucose had little effect on the response to vasoactive agents. Contractions with acetylcholine were depressed by anoxia in mesenteric and pulmonary strips but were augmented in saphenous veins; the latter potentiation was inhibited by iproveratril and by incubation in glucose free solution. Thus, especially in the saphenous vein, anaerobic glycolysis can provide most of the energy requirements, and intracellular substrates are available for oxidative metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/170516
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:46Z-
dc.date.available2012-10-30T06:09:46Z-
dc.date.issued1976en_US
dc.identifier.citationAmerican Journal Of Physiology, 1976, v. 230 n. 5, p. 1261-1268en_US
dc.identifier.urihttp://hdl.handle.net/10722/170516-
dc.description.abstractCanine vein strips were mounted for isometric tension recording. Anoxia did not affect basal tension of saphenous and pulmonary strips mounted in standard Krebs Ringer solution or after 30 min of incubation in glucose free solution. Anoxia depressed the strength of spontaneous contractions of mesenteric veins; in glucose free solution (30 min), anoxia relaxed the strips. Veins placed in glucose free solution for more than 60 min contracted with anoxia; this contraction was not inhibited by iproveratril. When the vein strips were contracted by norepinephrine or KCl, anoxia depressed the contractions, most in mesenteric and least in saphenous preparations; this depression was greater in the absence of glucose. When oxygen was present, the absence of glucose had little effect on the response to vasoactive agents. Contractions with acetylcholine were depressed by anoxia in mesenteric and pulmonary strips but were augmented in saphenous veins; the latter potentiation was inhibited by iproveratril and by incubation in glucose free solution. Thus, especially in the saphenous vein, anaerobic glycolysis can provide most of the energy requirements, and intracellular substrates are available for oxidative metabolism.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshDogsen_US
dc.subject.meshGlucose - Metabolismen_US
dc.subject.meshMesenteric Veins - Physiopathologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Physiopathologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshPulmonary Veins - Physiopathologyen_US
dc.subject.meshSaphenous Vein - Physiopathologyen_US
dc.subject.meshTetrodotoxin - Pharmacologyen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleEffects of anoxia and glucose depletion on isolated veins of the dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1275067-
dc.identifier.scopuseid_2-s2.0-0017158049en_US
dc.identifier.volume230en_US
dc.identifier.issue5en_US
dc.identifier.spage1261en_US
dc.identifier.epage1268en_US
dc.identifier.isiWOS:A1976BS46700014-
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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