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Article: Venomotor changes caused by halothane acting on the sympathetic nerves

TitleVenomotor changes caused by halothane acting on the sympathetic nerves
Authors
Issue Date1975
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.org
Citation
Anesthesiology, 1975, v. 43 n. 1, p. 41-48 How to Cite?
AbstractExperiments were performed to determine whether depression of venomotor responses with halothane results from interference with sympathetic activation or from an effect on venous smooth muscle cells. Changes in isometric tension of isolated canine saphenous vein strips were recorded. Adrenergic activation was achieved by transmural electrical stimulation, by addition of tyramine, and by addition of norepinephrine. Halothane (0.5 to 3 per cent) did not significantly alter basal tension. It lessened the reaction of the veins to electrical stimulation but not their response to norepinephrine; it increased the response to tyramine. Since the responses to norepinephrine and tyramine were not decreased, halothane appears to act on the nerve terminal to prevent release of neurotransmitter associated with nerve terminal depolarization. Thus, halothane causes inhibition of electrically induced venoconstriction in cutaneous veins, probably by interfering with the release of norepinephrine from nerve terminals rather than by an inhibitory effect on the smooth muscle cells.
Persistent Identifierhttp://hdl.handle.net/10722/170509
ISSN
2015 Impact Factor: 5.264
2015 SCImago Journal Rankings: 2.162
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMuldoon, SMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorLorenz, RRen_US
dc.contributor.authorVan Dyke, RAen_US
dc.date.accessioned2012-10-30T06:09:45Z-
dc.date.available2012-10-30T06:09:45Z-
dc.date.issued1975en_US
dc.identifier.citationAnesthesiology, 1975, v. 43 n. 1, p. 41-48en_US
dc.identifier.issn0003-3022en_US
dc.identifier.urihttp://hdl.handle.net/10722/170509-
dc.description.abstractExperiments were performed to determine whether depression of venomotor responses with halothane results from interference with sympathetic activation or from an effect on venous smooth muscle cells. Changes in isometric tension of isolated canine saphenous vein strips were recorded. Adrenergic activation was achieved by transmural electrical stimulation, by addition of tyramine, and by addition of norepinephrine. Halothane (0.5 to 3 per cent) did not significantly alter basal tension. It lessened the reaction of the veins to electrical stimulation but not their response to norepinephrine; it increased the response to tyramine. Since the responses to norepinephrine and tyramine were not decreased, halothane appears to act on the nerve terminal to prevent release of neurotransmitter associated with nerve terminal depolarization. Thus, halothane causes inhibition of electrically induced venoconstriction in cutaneous veins, probably by interfering with the release of norepinephrine from nerve terminals rather than by an inhibitory effect on the smooth muscle cells.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.orgen_US
dc.relation.ispartofAnesthesiologyen_US
dc.subject.meshAnesthesia, Inhalationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDepression, Chemicalen_US
dc.subject.meshDilatationen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHalothane - Pharmacologyen_US
dc.subject.meshMonoamine Oxidase Inhibitors - Pharmacologyen_US
dc.subject.meshMuscle, Smooth - Cytologyen_US
dc.subject.meshNerve Endings - Secretionen_US
dc.subject.meshNeurotransmitter Agents - Metabolismen_US
dc.subject.meshNorepinephrine - Metabolism - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Physiologyen_US
dc.subject.meshStimulation, Chemicalen_US
dc.subject.meshStress, Mechanicalen_US
dc.subject.meshSympathetic Nervous System - Drug Effectsen_US
dc.subject.meshSynaptic Transmissionen_US
dc.subject.meshTyramine - Pharmacologyen_US
dc.subject.meshVeins - Drug Effectsen_US
dc.titleVenomotor changes caused by halothane acting on the sympathetic nervesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00000542-197507000-00006-
dc.identifier.pmid238434-
dc.identifier.scopuseid_2-s2.0-0016837522en_US
dc.identifier.volume43en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage48en_US
dc.identifier.isiWOS:A1975AG89200005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMuldoon, SM=7006041150en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridLorenz, RR=7402095192en_US
dc.identifier.scopusauthoridVan Dyke, RA=7005816060en_US

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