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Article: Effects of local cooling on adrenergic neurotransmission in the dog's cutaneous vein

TitleEffects of local cooling on adrenergic neurotransmission in the dog's cutaneous vein
Authors
Issue Date1975
Citation
Archives Internationales De Pharmacodynamie Et De Therapie, 1975, v. 215 n. 2, p. 350 How to Cite?
AbstractExperiments were performed to investigate whether local cooling facilitates adrenergic neurotransmission in the dog's cutaneous vein. Helical strips of saphenous veins were incubated with 3H norepinephrine, and mounted for isometric tension recording and superfusion. The superfusate was collected for measurement of total radioactivity, or for chromatographic analysis. Electric stimulation (2 Hz) caused contraction and augmented the efflux of 3H norepinephrine and metabolites. Cooling (from 37 to 28° C) imposed during electric stimulation caused a further increase in tension, but decreased the amount of 3H norepinephrine and metabolites overflowing into the superfusate. These experiments demonstrate that the potentiating effect of cooling on the response of cutaneous veins to sympathetic nerve stimulation is not due in part to facilitation of adrenergic neurotransmission, but only reflects the greater affinity of the smooth muscle cells for the liberated transmitter.
Persistent Identifierhttp://hdl.handle.net/10722/170503
ISSN
1998 Impact Factor: 0.72
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorVerbeuren, TJen_US
dc.date.accessioned2012-10-30T06:09:44Z-
dc.date.available2012-10-30T06:09:44Z-
dc.date.issued1975en_US
dc.identifier.citationArchives Internationales De Pharmacodynamie Et De Therapie, 1975, v. 215 n. 2, p. 350en_US
dc.identifier.issn0003-9780en_US
dc.identifier.urihttp://hdl.handle.net/10722/170503-
dc.description.abstractExperiments were performed to investigate whether local cooling facilitates adrenergic neurotransmission in the dog's cutaneous vein. Helical strips of saphenous veins were incubated with 3H norepinephrine, and mounted for isometric tension recording and superfusion. The superfusate was collected for measurement of total radioactivity, or for chromatographic analysis. Electric stimulation (2 Hz) caused contraction and augmented the efflux of 3H norepinephrine and metabolites. Cooling (from 37 to 28° C) imposed during electric stimulation caused a further increase in tension, but decreased the amount of 3H norepinephrine and metabolites overflowing into the superfusate. These experiments demonstrate that the potentiating effect of cooling on the response of cutaneous veins to sympathetic nerve stimulation is not due in part to facilitation of adrenergic neurotransmission, but only reflects the greater affinity of the smooth muscle cells for the liberated transmitter.en_US
dc.languageengen_US
dc.relation.ispartofArchives Internationales de Pharmacodynamie et de Therapieen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshSympathetic Nervous System - Physiologyen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.titleEffects of local cooling on adrenergic neurotransmission in the dog's cutaneous veinen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid169757-
dc.identifier.scopuseid_2-s2.0-0016513291en_US
dc.identifier.volume215en_US
dc.identifier.issue2en_US
dc.identifier.spage350en_US
dc.identifier.isiWOS:A1975AE90300019-
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US

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