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Article: Effects of Beta-Glucans on Different Immune Cell Populations and Cancers

TitleEffects of Beta-Glucans on Different Immune Cell Populations and Cancers
Authors
KeywordsΒ-Glucan
Dectin-1
Dendritic Cells
Macrophages
Multi-Directional
Natural Killer Cells
Issue Date2012
Citation
Advances In Botanical Research, 2012, v. 62, p. 179-196 How to Cite?
Abstractβ-Glucan is one of the most abundant and widespread form of naturally occurring polysaccharides found inside the cell wall of bacteria, plants and fungi including the medicinal mushrooms. All forms of β-glucans have a basic structure of glucose polymers linked together by a 1 → 3 linear β-glycosidic chain core. They then differ from each other by their length of the core and the type and extent of branching structures of the two main forms of 1 → 4 or 1 → 6 glycosidic chains branching (Stone and Clarke, 1992). These branching assignments tend to be species specific, for instance, 1 → 6 side branches for fungal β-glucans in contrast to 1 → 4 side branches for bacterial β-glucans. There are insoluble or particulate forms versus the aqueous soluble forms of β-glucans which act on different target receptors. Various conformations such as triple helix, single helix or random coils also exist. The correlation between β-glucans structure and their biological potency has been elaborated in one of the recent reviews (Barsanti et al., 2011); our review will mainly focus at how β-glucans affect the diverse immunological cells and cytokines, especially those related to anti-cancer action. There are mounting evidences suggesting β-glucans as potent immunomodulators on both innate and adaptive immunity. After our previous review of the immunomodulatory and anti-cancer effects of β-glucans (Chan et al., 2009), there emerged a rich resource of studies on multi-directional immunomodulatory effects of β-glucans. The findings are complex and sometimes conflicting especially to the immune cell subsets. This review therefore aims to provide an up-to-date information on the effects of β-glucan to different immune cell populations and then postulate some possible translational strategies to utilize such knowledge in both anti-cancer research and clinical immunotherapeutic application. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/170468
ISSN
2015 Impact Factor: 1.204
2015 SCImago Journal Rankings: 0.619
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSze, DMYen_US
dc.contributor.authorChan, GCFen_US
dc.date.accessioned2012-10-30T06:09:12Z-
dc.date.available2012-10-30T06:09:12Z-
dc.date.issued2012en_US
dc.identifier.citationAdvances In Botanical Research, 2012, v. 62, p. 179-196en_US
dc.identifier.issn0065-2296en_US
dc.identifier.urihttp://hdl.handle.net/10722/170468-
dc.description.abstractβ-Glucan is one of the most abundant and widespread form of naturally occurring polysaccharides found inside the cell wall of bacteria, plants and fungi including the medicinal mushrooms. All forms of β-glucans have a basic structure of glucose polymers linked together by a 1 → 3 linear β-glycosidic chain core. They then differ from each other by their length of the core and the type and extent of branching structures of the two main forms of 1 → 4 or 1 → 6 glycosidic chains branching (Stone and Clarke, 1992). These branching assignments tend to be species specific, for instance, 1 → 6 side branches for fungal β-glucans in contrast to 1 → 4 side branches for bacterial β-glucans. There are insoluble or particulate forms versus the aqueous soluble forms of β-glucans which act on different target receptors. Various conformations such as triple helix, single helix or random coils also exist. The correlation between β-glucans structure and their biological potency has been elaborated in one of the recent reviews (Barsanti et al., 2011); our review will mainly focus at how β-glucans affect the diverse immunological cells and cytokines, especially those related to anti-cancer action. There are mounting evidences suggesting β-glucans as potent immunomodulators on both innate and adaptive immunity. After our previous review of the immunomodulatory and anti-cancer effects of β-glucans (Chan et al., 2009), there emerged a rich resource of studies on multi-directional immunomodulatory effects of β-glucans. The findings are complex and sometimes conflicting especially to the immune cell subsets. This review therefore aims to provide an up-to-date information on the effects of β-glucan to different immune cell populations and then postulate some possible translational strategies to utilize such knowledge in both anti-cancer research and clinical immunotherapeutic application. © 2012 Elsevier Ltd.en_US
dc.languageengen_US
dc.relation.ispartofAdvances in Botanical Researchen_US
dc.subjectΒ-Glucanen_US
dc.subjectDectin-1en_US
dc.subjectDendritic Cellsen_US
dc.subjectMacrophagesen_US
dc.subjectMulti-Directionalen_US
dc.subjectNatural Killer Cellsen_US
dc.titleEffects of Beta-Glucans on Different Immune Cell Populations and Cancersen_US
dc.typeArticleen_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/B978-0-12-394591-4.00011-8en_US
dc.identifier.scopuseid_2-s2.0-84862669347en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862669347&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.spage179en_US
dc.identifier.epage196en_US
dc.identifier.isiWOS:000308203700006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSze, DMY=7005428465en_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US

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