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Article: Diastolic ventricular interaction in patients after atrial switch for transposition of the great arteries: A speckle tracking echocardiographic study

TitleDiastolic ventricular interaction in patients after atrial switch for transposition of the great arteries: A speckle tracking echocardiographic study
Authors
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2011, v. 152 n. 1, p. 28-34 How to Cite?
AbstractBackground: We tested the hypothesis that diastolic ventricular interaction occurs after atrial switch operation for transposition of the great arteries (TGA) and that subpulmonary LV diastolic function is influenced by septal geometry. Methods: Twenty-nine patients (male 19) after atrial switch operation for TGA aged 20.8 ± 4.1 years and 27 healthy controls were studied. Two-dimensional longitudinal systolic strain, systolic (SRs), early diastolic (SRe), and late diastolic (SRa) strain rates of both ventricles were determined using speckle tracking echocardiography. Early diastolic trans-atrioventricular velocity (E) and myocardial early diastolic myocardial velocity (e) at the ventricular free wall-annular junction were measured. Geometry of the morphologic left ventricle was quantified by the diastolic eccentricity index (EI). Results: In both systemic and subpulmonary ventricles, SRe and SRa were significantly lower and trans-atrioventricular E/e ratios higher in patients than controls (all p < 0.001). In patients, RV SRe correlated with left ventricular (LV) SRe (r = 0.49, p = 0.008), and RV SRa correlated with LV SRa (r = 0.46, p = 0.01). Significant leftward shifting of the septum in patients was reflected by the greater LV EI (p < 0.001). In patients, LV EI correlated with age- and sex-adjusted z score of LV end-diastolic volume. As a group, LV EI correlated negatively with LV SRe (r =-0.62, p < 0.001) and LV SRa (r = - 0.51, p < 0.001), and positively with mitral E/e ratio (r = 0.33, p = 0.02). Conclusions: Systemic RV diastolic dysfunction occurs after atrial switch operation and correlates with subpulmonary LV diastolic dysfunction. The observed diastolic ventricular interaction may potentially be mediated through alteration of septal geometry. © 2010 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170460
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, PCen_US
dc.contributor.authorLiang, XCen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-10-30T06:09:07Z-
dc.date.available2012-10-30T06:09:07Z-
dc.date.issued2011en_US
dc.identifier.citationInternational Journal Of Cardiology, 2011, v. 152 n. 1, p. 28-34en_US
dc.identifier.issn0167-5273en_US
dc.identifier.urihttp://hdl.handle.net/10722/170460-
dc.description.abstractBackground: We tested the hypothesis that diastolic ventricular interaction occurs after atrial switch operation for transposition of the great arteries (TGA) and that subpulmonary LV diastolic function is influenced by septal geometry. Methods: Twenty-nine patients (male 19) after atrial switch operation for TGA aged 20.8 ± 4.1 years and 27 healthy controls were studied. Two-dimensional longitudinal systolic strain, systolic (SRs), early diastolic (SRe), and late diastolic (SRa) strain rates of both ventricles were determined using speckle tracking echocardiography. Early diastolic trans-atrioventricular velocity (E) and myocardial early diastolic myocardial velocity (e) at the ventricular free wall-annular junction were measured. Geometry of the morphologic left ventricle was quantified by the diastolic eccentricity index (EI). Results: In both systemic and subpulmonary ventricles, SRe and SRa were significantly lower and trans-atrioventricular E/e ratios higher in patients than controls (all p < 0.001). In patients, RV SRe correlated with left ventricular (LV) SRe (r = 0.49, p = 0.008), and RV SRa correlated with LV SRa (r = 0.46, p = 0.01). Significant leftward shifting of the septum in patients was reflected by the greater LV EI (p < 0.001). In patients, LV EI correlated with age- and sex-adjusted z score of LV end-diastolic volume. As a group, LV EI correlated negatively with LV SRe (r =-0.62, p < 0.001) and LV SRa (r = - 0.51, p < 0.001), and positively with mitral E/e ratio (r = 0.33, p = 0.02). Conclusions: Systemic RV diastolic dysfunction occurs after atrial switch operation and correlates with subpulmonary LV diastolic dysfunction. The observed diastolic ventricular interaction may potentially be mediated through alteration of septal geometry. © 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshCardiac Surgical Procedures - Methodsen_US
dc.subject.meshDiastole - Physiologyen_US
dc.subject.meshEchocardiography - Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension, Pulmonary - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPostoperative Complications - Physiopathology - Ultrasonographyen_US
dc.subject.meshSystole - Physiologyen_US
dc.subject.meshTransposition Of Great Vessels - Physiopathology - Surgeryen_US
dc.subject.meshVentricular Dysfunction, Left - Physiopathology - Ultrasonographyen_US
dc.subject.meshYoung Adulten_US
dc.titleDiastolic ventricular interaction in patients after atrial switch for transposition of the great arteries: A speckle tracking echocardiographic studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijcard.2010.05.078en_US
dc.identifier.pmid20621369-
dc.identifier.scopuseid_2-s2.0-80053570717en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053570717&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume152en_US
dc.identifier.issue1en_US
dc.identifier.spage28en_US
dc.identifier.epage34en_US
dc.identifier.isiWOS:000296478300007-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridChow, PC=23099233800en_US
dc.identifier.scopusauthoridLiang, XC=12803290200en_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US
dc.identifier.citeulike7603429-

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