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Article: Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy

TitleGene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy
Authors
Issue Date2011
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/pgs
Citation
Pharmacogenomics, 2011, v. 12 n. 3, p. 319-325 How to Cite?
AbstractAim: To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. Results: Genotype distributions of all the selected SNPs were consistent with Hardy-â€"Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug resistance. For each gene, no haplotypes of over 1% frequency, and that included all SNPs of the gene, were associated with drug resistance. Conclusion: This gene-wide tagging study revealed no association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy. © 2011 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/170448
ISSN
2015 Impact Factor: 2.71
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwan, Pen_US
dc.contributor.authorWong, Ven_US
dc.contributor.authorNg, PWen_US
dc.contributor.authorLui, CHTen_US
dc.contributor.authorSin, NCen_US
dc.contributor.authorWong, KSen_US
dc.contributor.authorBaum, Len_US
dc.date.accessioned2012-10-30T06:09:00Z-
dc.date.available2012-10-30T06:09:00Z-
dc.date.issued2011en_US
dc.identifier.citationPharmacogenomics, 2011, v. 12 n. 3, p. 319-325en_US
dc.identifier.issn1462-2416en_US
dc.identifier.urihttp://hdl.handle.net/10722/170448-
dc.description.abstractAim: To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. Results: Genotype distributions of all the selected SNPs were consistent with Hardy-â€"Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug resistance. For each gene, no haplotypes of over 1% frequency, and that included all SNPs of the gene, were associated with drug resistance. Conclusion: This gene-wide tagging study revealed no association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy. © 2011 Future Medicine Ltd.en_US
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/pgsen_US
dc.relation.ispartofPharmacogenomicsen_US
dc.subject.meshAtp-Binding Cassette Transporters - Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAllelesen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshDrug Resistance, Multiple - Geneticsen_US
dc.subject.meshEpilepsy - Drug Therapy - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultidrug Resistance-Associated Proteins - Geneticsen_US
dc.subject.meshNeoplasm Proteins - Geneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPolymorphism, Single Nucleotide - Geneticsen_US
dc.subject.meshYoung Adulten_US
dc.titleGene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsyen_US
dc.typeArticleen_US
dc.identifier.emailWong, V:vcnwong@hku.hken_US
dc.identifier.authorityWong, V=rp00334en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2217/pgs.10.183en_US
dc.identifier.pmid21449672-
dc.identifier.scopuseid_2-s2.0-79953235784en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953235784&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue3en_US
dc.identifier.spage319en_US
dc.identifier.epage325en_US
dc.identifier.isiWOS:000289707400012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKwan, P=7004369601en_US
dc.identifier.scopusauthoridWong, V=7202525632en_US
dc.identifier.scopusauthoridNg, PW=7201376949en_US
dc.identifier.scopusauthoridLui, CHT=36943011700en_US
dc.identifier.scopusauthoridSin, NC=6602256513en_US
dc.identifier.scopusauthoridWong, KS=7404759405en_US
dc.identifier.scopusauthoridBaum, L=7103310839en_US
dc.identifier.citeulike9107192-

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