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- Publisher Website: 10.1007/s12519-010-0019-0
- Scopus: eid_2-s2.0-77954658970
- PMID: 20127220
- WOS: WOS:000277775800006
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Article: Mycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naïve T cells into a tolerogenic phenotype in newborns
Title | Mycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naïve T cells into a tolerogenic phenotype in newborns |
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Authors | |
Keywords | Bacillus Calmette-Guerin Cord blood Dendritic cells Newborns T cells Tolerance |
Issue Date | 2010 |
Publisher | Zhejiang University, School of Medicine Children's Hospital. The Journal's web site is located at http://www.wjpch.com |
Citation | World Journal Of Pediatrics, 2010, v. 6 n. 2, p. 132-140 How to Cite? |
Abstract | Background: As one of the first infectious challenges of life, the impact of neonatal Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccination on the polarization of neonatal T helper subset has not been well defined. Methods: We investigated the effect of BCG-treated cord blood (CB) dendritic cells (DCs) on naïve CD4+ T cells polarization compared with that of adult blood DCs. Results: BCG-treated CB DCs had significantly lower expression of CD83 and a higher ratio of CD47/Fas than BCG-treated adult blood DCs. BCG induced significantly lower IL-12 but relatively higher IL-10 production from CB DCs than adult blood DCs. Moreover, in comparison with BCG-treated adult blood DCs, BCG-treated CB DCs induced higher IL-10 production and cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression, and lower interferon-gamma (IFN-γ) production from naïve CD4+ T cells. On the other hand, lipopolysaccharide- treated CB DCs had similar capacity as prime naïve CD4+ T cells did to produce higher IFN-γ, lower IL-10 production, and CTLA-4 expression compared with their adult counterparts. Conclusion: These results suggested that BCG-treated CB DCs might be semi-mature DCs which polarize naïve T cells into a tolerogenic T cell phenotype in newborns. ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2010. |
Persistent Identifier | http://hdl.handle.net/10722/170440 |
ISSN | 2021 Impact Factor: 9.186 2020 SCImago Journal Rankings: 0.646 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, EM | en_US |
dc.contributor.author | Law, HKW | en_US |
dc.contributor.author | Lau, YL | en_US |
dc.date.accessioned | 2012-10-30T06:08:47Z | - |
dc.date.available | 2012-10-30T06:08:47Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | World Journal Of Pediatrics, 2010, v. 6 n. 2, p. 132-140 | en_US |
dc.identifier.issn | 1708-8569 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170440 | - |
dc.description.abstract | Background: As one of the first infectious challenges of life, the impact of neonatal Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccination on the polarization of neonatal T helper subset has not been well defined. Methods: We investigated the effect of BCG-treated cord blood (CB) dendritic cells (DCs) on naïve CD4+ T cells polarization compared with that of adult blood DCs. Results: BCG-treated CB DCs had significantly lower expression of CD83 and a higher ratio of CD47/Fas than BCG-treated adult blood DCs. BCG induced significantly lower IL-12 but relatively higher IL-10 production from CB DCs than adult blood DCs. Moreover, in comparison with BCG-treated adult blood DCs, BCG-treated CB DCs induced higher IL-10 production and cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression, and lower interferon-gamma (IFN-γ) production from naïve CD4+ T cells. On the other hand, lipopolysaccharide- treated CB DCs had similar capacity as prime naïve CD4+ T cells did to produce higher IFN-γ, lower IL-10 production, and CTLA-4 expression compared with their adult counterparts. Conclusion: These results suggested that BCG-treated CB DCs might be semi-mature DCs which polarize naïve T cells into a tolerogenic T cell phenotype in newborns. ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2010. | en_US |
dc.language | eng | en_US |
dc.publisher | Zhejiang University, School of Medicine Children's Hospital. The Journal's web site is located at http://www.wjpch.com | en_US |
dc.relation.ispartof | World Journal of Pediatrics | en_US |
dc.subject | Bacillus Calmette-Guerin | - |
dc.subject | Cord blood | - |
dc.subject | Dendritic cells | - |
dc.subject | Newborns | - |
dc.subject | T cells | - |
dc.subject | Tolerance | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Antigens, Cd - Metabolism | en_US |
dc.subject.mesh | Bcg Vaccine | en_US |
dc.subject.mesh | Cd4-Positive T-Lymphocytes - Immunology | en_US |
dc.subject.mesh | Ctla-4 Antigen | en_US |
dc.subject.mesh | Cells, Cultured | en_US |
dc.subject.mesh | Dendritic Cells - Immunology - Metabolism | en_US |
dc.subject.mesh | Fetal Blood - Cytology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infant, Newborn | en_US |
dc.subject.mesh | Interferon-Gamma - Metabolism | en_US |
dc.subject.mesh | Interleukins - Metabolism | en_US |
dc.subject.mesh | Monocytes - Cytology | en_US |
dc.subject.mesh | Mycobacterium Bovis - Immunology | en_US |
dc.subject.mesh | Up-Regulation | en_US |
dc.title | Mycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naïve T cells into a tolerogenic phenotype in newborns | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lau, YL:lauylung@hkucc.hku.hk | en_US |
dc.identifier.authority | Lau, YL=rp00361 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s12519-010-0019-0 | en_US |
dc.identifier.pmid | 20127220 | - |
dc.identifier.scopus | eid_2-s2.0-77954658970 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77954658970&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 132 | en_US |
dc.identifier.epage | 140 | en_US |
dc.identifier.isi | WOS:000277775800006 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Liu, EM=7202240063 | en_US |
dc.identifier.scopusauthorid | Law, HKW=7101939394 | en_US |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_US |
dc.identifier.citeulike | 6799765 | - |