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Article: Mycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naïve T cells into a tolerogenic phenotype in newborns

TitleMycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naïve T cells into a tolerogenic phenotype in newborns
Authors
Issue Date2010
PublisherZhejiang University, School of Medicine Children's Hospital. The Journal's web site is located at http://www.wjpch.com
Citation
World Journal Of Pediatrics, 2010, v. 6 n. 2, p. 132-140 How to Cite?
AbstractBackground: As one of the first infectious challenges of life, the impact of neonatal Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccination on the polarization of neonatal T helper subset has not been well defined. Methods: We investigated the effect of BCG-treated cord blood (CB) dendritic cells (DCs) on naïve CD4+ T cells polarization compared with that of adult blood DCs. Results: BCG-treated CB DCs had significantly lower expression of CD83 and a higher ratio of CD47/Fas than BCG-treated adult blood DCs. BCG induced significantly lower IL-12 but relatively higher IL-10 production from CB DCs than adult blood DCs. Moreover, in comparison with BCG-treated adult blood DCs, BCG-treated CB DCs induced higher IL-10 production and cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression, and lower interferon-gamma (IFN-γ) production from naïve CD4+ T cells. On the other hand, lipopolysaccharide- treated CB DCs had similar capacity as prime naïve CD4+ T cells did to produce higher IFN-γ, lower IL-10 production, and CTLA-4 expression compared with their adult counterparts. Conclusion: These results suggested that BCG-treated CB DCs might be semi-mature DCs which polarize naïve T cells into a tolerogenic T cell phenotype in newborns. ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2010.
Persistent Identifierhttp://hdl.handle.net/10722/170440
ISSN
2015 Impact Factor: 1.025
2015 SCImago Journal Rankings: 0.493
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, EMen_US
dc.contributor.authorLaw, HKWen_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2012-10-30T06:08:47Z-
dc.date.available2012-10-30T06:08:47Z-
dc.date.issued2010en_US
dc.identifier.citationWorld Journal Of Pediatrics, 2010, v. 6 n. 2, p. 132-140en_US
dc.identifier.issn1708-8569en_US
dc.identifier.urihttp://hdl.handle.net/10722/170440-
dc.description.abstractBackground: As one of the first infectious challenges of life, the impact of neonatal Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccination on the polarization of neonatal T helper subset has not been well defined. Methods: We investigated the effect of BCG-treated cord blood (CB) dendritic cells (DCs) on naïve CD4+ T cells polarization compared with that of adult blood DCs. Results: BCG-treated CB DCs had significantly lower expression of CD83 and a higher ratio of CD47/Fas than BCG-treated adult blood DCs. BCG induced significantly lower IL-12 but relatively higher IL-10 production from CB DCs than adult blood DCs. Moreover, in comparison with BCG-treated adult blood DCs, BCG-treated CB DCs induced higher IL-10 production and cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression, and lower interferon-gamma (IFN-γ) production from naïve CD4+ T cells. On the other hand, lipopolysaccharide- treated CB DCs had similar capacity as prime naïve CD4+ T cells did to produce higher IFN-γ, lower IL-10 production, and CTLA-4 expression compared with their adult counterparts. Conclusion: These results suggested that BCG-treated CB DCs might be semi-mature DCs which polarize naïve T cells into a tolerogenic T cell phenotype in newborns. ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2010.en_US
dc.languageengen_US
dc.publisherZhejiang University, School of Medicine Children's Hospital. The Journal's web site is located at http://www.wjpch.comen_US
dc.relation.ispartofWorld Journal of Pediatricsen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Cd - Metabolismen_US
dc.subject.meshBcg Vaccineen_US
dc.subject.meshCd4-Positive T-Lymphocytes - Immunologyen_US
dc.subject.meshCtla-4 Antigenen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDendritic Cells - Immunology - Metabolismen_US
dc.subject.meshFetal Blood - Cytologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInterferon-Gamma - Metabolismen_US
dc.subject.meshInterleukins - Metabolismen_US
dc.subject.meshMonocytes - Cytologyen_US
dc.subject.meshMycobacterium Bovis - Immunologyen_US
dc.subject.meshUp-Regulationen_US
dc.titleMycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naïve T cells into a tolerogenic phenotype in newbornsen_US
dc.typeArticleen_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12519-010-0019-0en_US
dc.identifier.pmid20127220-
dc.identifier.scopuseid_2-s2.0-77954658970en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954658970&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue2en_US
dc.identifier.spage132en_US
dc.identifier.epage140en_US
dc.identifier.isiWOS:000277775800006-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLiu, EM=7202240063en_US
dc.identifier.scopusauthoridLaw, HKW=7101939394en_US
dc.identifier.scopusauthoridLau, YL=7201403380en_US
dc.identifier.citeulike6799765-

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