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Article: Restrictive right ventricular physiology and right ventricular fibrosis as assessed by cardiac magnetic resonance and exercise capacity after biventricular repair of pulmonary atresia and intact ventricular septum

TitleRestrictive right ventricular physiology and right ventricular fibrosis as assessed by cardiac magnetic resonance and exercise capacity after biventricular repair of pulmonary atresia and intact ventricular septum
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.clinicalcardiology.org
Citation
Clinical Cardiology, 2010, v. 33 n. 2, p. 104-110 How to Cite?
AbstractBackground: The hypertrophic myocardium, myocardial fiber disarray, and endocardial fibroelastosis in pulmonary atresia and intact ventricularseptum(PAIVS)may provide anatomic substrates for restrictivefilling of the right ventricle. Hypothesis: Restrictiveright ventricle (RV) physiology is relatedto RV fibrosis and exercise capacity in patients after biventricular repair of PAIVS. Methods: A total of 27 patients, age 16.5 ± 5.6 years, were recruited after biventricular repair of PAIVS. Restrictive RV physiology was defined by the presence of antegrade diastolic pulmonary flow and RV fibrosis assessedby late gadoliniumenhancement (LGE) cardiacmagnetic resonance. Their RV functionwas compared with that of 27 healthy controls and related to RV LGE score and exercise capacity. Results: Compared with controls, PAIVS patients had lower tricuspid annular systolic and early diastolic velocities, RV global longitudinal systolic strain, systolic strain rate, and early and late diastolic strain rates (all P < 0.05). A total of 22 (81%, 95%confidence interval: 62%-94%) PAIVS patients demonstrated restrictive RV physiology. Compared to those without restrictive RV physiology (n=5), these 22 patients had lower RV global systolic strain, lower RV systolic and early diastolic strain rates, higher RV LGE score, and a greater percent of predicted maximum oxygen consumption (all P < 0.05). Conclusion: Restrictive RV physiology reflects RV diastolic dysfunction and is associatedwith more severe RV fibrosis but better exercise capacity in patients after biventricular repair of PAIVS. © 2010 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/170435
ISSN
2015 Impact Factor: 2.431
2015 SCImago Journal Rankings: 1.309
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiang, XCen_US
dc.contributor.authorLam, WWMen_US
dc.contributor.authorCheung, EWYen_US
dc.contributor.authorWu, AKPen_US
dc.contributor.authorWong, SJen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-10-30T06:08:33Z-
dc.date.available2012-10-30T06:08:33Z-
dc.date.issued2010en_US
dc.identifier.citationClinical Cardiology, 2010, v. 33 n. 2, p. 104-110en_US
dc.identifier.issn0160-9289en_US
dc.identifier.urihttp://hdl.handle.net/10722/170435-
dc.description.abstractBackground: The hypertrophic myocardium, myocardial fiber disarray, and endocardial fibroelastosis in pulmonary atresia and intact ventricularseptum(PAIVS)may provide anatomic substrates for restrictivefilling of the right ventricle. Hypothesis: Restrictiveright ventricle (RV) physiology is relatedto RV fibrosis and exercise capacity in patients after biventricular repair of PAIVS. Methods: A total of 27 patients, age 16.5 ± 5.6 years, were recruited after biventricular repair of PAIVS. Restrictive RV physiology was defined by the presence of antegrade diastolic pulmonary flow and RV fibrosis assessedby late gadoliniumenhancement (LGE) cardiacmagnetic resonance. Their RV functionwas compared with that of 27 healthy controls and related to RV LGE score and exercise capacity. Results: Compared with controls, PAIVS patients had lower tricuspid annular systolic and early diastolic velocities, RV global longitudinal systolic strain, systolic strain rate, and early and late diastolic strain rates (all P < 0.05). A total of 22 (81%, 95%confidence interval: 62%-94%) PAIVS patients demonstrated restrictive RV physiology. Compared to those without restrictive RV physiology (n=5), these 22 patients had lower RV global systolic strain, lower RV systolic and early diastolic strain rates, higher RV LGE score, and a greater percent of predicted maximum oxygen consumption (all P < 0.05). Conclusion: Restrictive RV physiology reflects RV diastolic dysfunction and is associatedwith more severe RV fibrosis but better exercise capacity in patients after biventricular repair of PAIVS. © 2010 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.clinicalcardiology.orgen_US
dc.relation.ispartofClinical Cardiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshBalloon Dilationen_US
dc.subject.meshCardiac Surgical Procedures - Adverse Effectsen_US
dc.subject.meshCardiomyopathy, Restrictive - Diagnosis - Etiology - Physiopathologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshContrast Media - Diagnostic Useen_US
dc.subject.meshEchocardiography, Doppleren_US
dc.subject.meshExercise Testen_US
dc.subject.meshExercise Toleranceen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrosisen_US
dc.subject.meshGadolinium Dtpa - Diagnostic Useen_US
dc.subject.meshHeart Ventricles - Pathology - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshOxygen Consumptionen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPulmonary Atresia - Complications - Diagnosis - Physiopathology - Surgeryen_US
dc.subject.meshPulmonary Circulationen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVentricular Dysfunction, Right - Diagnosis - Etiology - Physiopathologyen_US
dc.subject.meshVentricular Function, Righten_US
dc.subject.meshYoung Adulten_US
dc.titleRestrictive right ventricular physiology and right ventricular fibrosis as assessed by cardiac magnetic resonance and exercise capacity after biventricular repair of pulmonary atresia and intact ventricular septumen_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/clc.20711en_US
dc.identifier.pmid20186992-
dc.identifier.scopuseid_2-s2.0-77649245272en_US
dc.identifier.hkuros169055-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77649245272&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue2en_US
dc.identifier.spage104en_US
dc.identifier.epage110en_US
dc.identifier.isiWOS:000274990700010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiang, XC=12803290200en_US
dc.identifier.scopusauthoridLam, WWM=35292558200en_US
dc.identifier.scopusauthoridCheung, EWY=9432819700en_US
dc.identifier.scopusauthoridWu, AKP=36878644300en_US
dc.identifier.scopusauthoridWong, SJ=25924109100en_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US

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